AC   MF_02089;
DC   Protein; auto
TR   HAMAP; MF_02089; -; 1; level=0
XX
Names: QueH
XX
ID   QUEH
DE   RecName: Full=Epoxyqueuosine reductase QueH;
DE            EC=1.17.99.6;
DE   AltName: Full=Queuosine biosynthesis protein QueH;
GN   Name=queH;
XX
CC   -!- FUNCTION: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine
CC       (Q), which is a hypermodified base found in the wobble positions of
CC       tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in
CC         tRNA; Xref=Rhea:RHEA:32159, Rhea:RHEA-COMP:18571, Rhea:RHEA-
CC         COMP:18582, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499,
CC         ChEBI:CHEBI:194431, ChEBI:CHEBI:194443; EC=1.17.99.6;
CC   -!- PATHWAY: tRNA modification; tRNA-queuosine biosynthesis.
CC   -!- SIMILARITY: Belongs to the QueH family.
XX
DR   Pfam; PF02677; DUF208; 1; trigger=no
XX
case <FTGroup:1>
KW   4Fe-4S
KW   Iron
KW   Iron-sulfur
KW   Metal-binding
end case
KW   Disulfide bond
KW   Oxidoreductase
KW   Queuosine biosynthesis
KW   Redox-active center
KW   tRNA processing
XX
GO   GO:0052693; F:epoxyqueuosine reductase activity
case <FTGroup:1>
GO   GO:0051539; F:4 iron, 4 sulfur cluster binding
end case
GO   GO:0008616; P:queuosine biosynthetic process
GO   GO:0006400; P:tRNA modification
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FT   From: QUEH_STAAM (A0A0H3JUG6)
FT   BINDING         43
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         44
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         129
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         132
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   DISULFID        211..213
FT                   /note="Redox-active"
FT   Condition: C-x*-C
XX
Size: 170-370;
Related: None;
Template: A0A0H3JUG6; Q7VYQ1; Q3Z8V0; Q0I1Q0; A0A0H2VKG8; Q9A1K3; Q9WZJ0; O24926;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Longer C-terminal domain in some species.
XX
# Revision 1.7 2024/01/31
//