AC   MF_02092;
DC   Protein; auto
TR   HAMAP; MF_02092; -; 1; level=0
XX
Names: DLDH_Dld
XX
ID   DLD
DE   RecName: Full=Quinone-dependent D-lactate dehydrogenase;
DE            EC=1.1.5.12;
DE   AltName: Full=D-lactate dehydrogenase;
DE            Short=D-LDH;
GN   Name=dld;
XX
CC   -!- FUNCTION: Catalyzes the oxidation of D-lactate to pyruvate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-lactate + a quinone = a quinol + pyruvate;
CC         Xref=Rhea:RHEA:51468, ChEBI:CHEBI:15361, ChEBI:CHEBI:16004,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.12;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>)
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein;
CC       Cytoplasmic side.
else
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein;
CC       Cytoplasmic side.
end case
CC   -!- SIMILARITY: Belongs to the quinone-dependent D-lactate dehydrogenase
CC       family.
XX
DR   PROSITE; PS51387; FAD_PCMH; 1; trigger=yes
DR   Pfam; PF01565; FAD_binding_4; 1; trigger=no
DR   Pfam; PF09330; Lact-deh-memb; 1; trigger=no
DR   PIRSF; PIRSF000101; D-lactate_dh; 1; trigger=no
XX
case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>)
KW   Cell inner membrane
end case
KW   Cell membrane
KW   FAD
KW   Flavoprotein
KW   Membrane
KW   Oxidoreductase
KW   Quinone
XX
GO   GO:0016901; F:oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
GO   GO:0050660; F:flavin adenine dinucleotide binding
GO   GO:0019516; P:lactate oxidation
GO   GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane
XX
FT   From: DLD_ECOLI (P06149)
FT   BINDING         76..80
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT   Condition: [AS]-[AS]-[NK]-T-[GS]
FT   BINDING         84..85
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT   Condition: G-S
FT   BINDING         143
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT   Condition: G
FT   BINDING         150
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT   Condition: [ST]
FT   BINDING         160
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT   Condition: G
FT   BINDING         262
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT   Condition: [VLI]
XX
Size: 550-610;
Related: None;
Template: P06149; Q8NRY8;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2023/01/26
//