AC   MF_02097;
DC   Protein; auto
TR   HAMAP; MF_02097; -; 1; level=0
XX
Names: Carnitine_monoox_A
XX
ID   CNTA
DE   RecName: Full=Carnitine monooxygenase oxygenase subunit;
DE            EC=1.14.13.239;
DE   AltName: Full=Carnitine monooxygenase alpha subunit;
XX
CC   -!- FUNCTION: Converts carnitine to trimethylamine and malic semialdehyde.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4-
CC         oxobutanoate + H2O + NAD(+) + trimethylamine; Xref=Rhea:RHEA:55396,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16347, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:58389, ChEBI:CHEBI:138809; EC=1.14.13.239;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4-
CC         oxobutanoate + H2O + NADP(+) + trimethylamine; Xref=Rhea:RHEA:55368,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16347, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:58389, ChEBI:CHEBI:138809; EC=1.14.13.239;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC       Note=Binds 1 [2Fe-2S] cluster per subunit.;
end case
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC       Note=Binds 1 Fe cation per subunit
CC   -!- PATHWAY: Amine and polyamine metabolism; carnitine metabolism.
CC   -!- SUBUNIT: Composed of an oxygenase subunit and a reductase subunit.
CC   -!- SIMILARITY: Belongs to the bacterial ring-hydroxylating dioxygenase
CC       alpha subunit family. CntA subfamily.
XX
DR   PROSITE; PS51296; RIESKE; 1; trigger=yes
DR   PROSITE; PS00570; RING_HYDROXYL_ALPHA; 1; trigger=no
DR   Pfam; PF00355; Rieske; 1; trigger=no
DR   Pfam; PF00848; Ring_hydroxyl_A; 1; trigger=no
DR   PRINTS; PR00090; RNGDIOXGNASE; 1; trigger=no
XX
case <FTGroup:1>
KW   2Fe-2S
KW   Iron-sulfur
end case
KW   Iron
KW   Metal-binding
KW   NAD
KW   NADP
KW   Oxidoreductase
XX
GO   GO:0016709; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
case <FTGroup:1>
GO   GO:0051537; F:2 iron, 2 sulfur cluster binding
end case
XX
FT   From: CNTA_ACIB2 (D0C9N6)
FT   BINDING         86
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT   Group: 1; Condition: C
FT   BINDING         88
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT   Group: 1; Condition: H
FT   BINDING         106
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT   Group: 1; Condition: C
FT   BINDING         109
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT   Group: 1; Condition: H
FT   BINDING         208
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Condition: H
FT   BINDING         213
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Condition: H
FT   BINDING         323
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Condition: D
XX
Size: 365-405;
Related: None;
Template: D0C9N6; F0KFI5; P0ABR7;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: See MF_02098 for the reductase subunit.
XX
# Revision 1.8 2023/01/26
//