AC   MF_02102;
DC   Protein; auto
TR   HAMAP; MF_02102; -; 1; level=0
XX
Names: PTCase
XX
ID   PTC
DE   RecName: Full=Putrescine carbamoyltransferase;
DE            Short=PTC;
DE            Short=PTCase;
DE            EC=2.1.3.6;
DE   AltName: Full=Putrescine transcarbamoylase;
DE   AltName: Full=Putrescine transcarbamylase;
GN   Name=ptcA;
XX
CC   -!- FUNCTION: Catalyzes the phosphorolysis of N-carbamoylputrescine to form
CC       carbamoyl phosphate and putrescine. Is involved in the degradation
CC       pathway of the polyamine agmatine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=carbamoyl phosphate + putrescine = H(+) + N-
CC         carbamoylputrescine + phosphate; Xref=Rhea:RHEA:21936,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58228,
CC         ChEBI:CHEBI:58318, ChEBI:CHEBI:326268; EC=2.1.3.6;
CC   -!- PATHWAY: Amine and polyamine biosynthesis; putrescine biosynthesis via
CC       agmatine pathway; putrescine from N-carbamoylputrescine (transferase
CC       route): step 1/1.
CC   -!- SUBUNIT: Homotrimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase
CC       superfamily. PTCase family.
XX
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1; trigger=no
DR   Pfam; PF00185; OTCace; 1; trigger=no
DR   Pfam; PF02729; OTCace_N; 1; trigger=no
DR   PRINTS; PR00100; AOTCASE; 1; trigger=no
DR   PRINTS; PR00102; OTCASE; 1; trigger=no
DR   NCBIfam; TIGR00658; Orni_carb_tr; 1; trigger=no
XX
KW   Cytoplasm
KW   Polyamine biosynthesis
KW   Transferase
XX
GO   GO:0050231; F:putrescine carbamoyltransferase activity
GO   GO:0033390; P:putrescine biosynthetic process from arginine via N-carbamoylputrescine
XX
FT   From: PTC_ENTFA (Q837U7)
FT   BINDING         52..56
FT                   /ligand="carbamoyl phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58228"
FT   Condition: S-T-R-T-R
FT   BINDING         268..271
FT                   /ligand="putrescine"
FT                   /ligand_id="ChEBI:CHEBI:326268"
FT   Condition: H-C-L-P
FT   BINDING         103
FT                   /ligand="carbamoyl phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58228"
FT   Condition: R
FT   BINDING         130
FT                   /ligand="carbamoyl phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58228"
FT   Condition: H
FT   SITE            27
FT                   /note="Important for structural integrity"
FT   Condition: K
FT   SITE            143
FT                   /note="Important for structural integrity"
FT   Condition: E
XX
Size: 339-365;
Related: MF_01109;
Template: Q837U7; Q8DW19;
Scope:
 Bacteria; Bacillota
 Bacteria; Mycoplasmatota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.15 2023/06/01
//