AC   MF_02103;
DC   Protein; auto
TR   HAMAP; MF_02103; -; 1; level=0
XX
Names: LutB
XX
ID   LUTB
DE   RecName: Full=Lactate utilization protein B;
GN   Name=lutB;
XX
CC   -!- FUNCTION: Is involved in L-lactate degradation and allows cells to grow
CC       with lactate as the sole carbon source. Has probably a role as an
CC       electron transporter during oxidation of L-lactate.
CC   -!- SIMILARITY: Belongs to the LutB/YkgF family.
XX
DR   PROSITE; PS00198; 4FE4S_FER_1; 2; trigger=no
DR   PROSITE; PS51379; 4FE4S_FER_2; 2; trigger=no
DR   Pfam; PF02589; DUF162; 1; trigger=no
DR   NCBIfam; TIGR00273; TIGR00273; 1; trigger=no
XX
KW   4Fe-4S
KW   Electron transport
KW   Iron
KW   Iron-sulfur
KW   Metal-binding
KW   Repeat
KW   Transport
XX
GO   GO:0051536; F:iron-sulfur cluster binding
GO   GO:0006089; P:lactate metabolic process
GO   GO:0019516; P:lactate oxidation
XX
FT   From: LUTB_BACSU (O07021)
FT   DOMAIN          304..334
FT                   /note="4Fe-4S ferredoxin-type 1"
FT   DOMAIN          353..382
FT                   /note="4Fe-4S ferredoxin-type 2"
FT   BINDING         313
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT   Condition: C
FT   BINDING         316
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT   Condition: C
FT   BINDING         319
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT   Condition: C
FT   BINDING         323
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT   Condition: C
FT   BINDING         366
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT   Condition: C
FT   BINDING         369
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="2"
FT   Condition: C
FT   BINDING         373
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_label="1"
FT   Condition: C
XX
Size: 468-485;
Related: None;
Template: O07021; Q81GA4;
Scope:
 Bacteria; Bacillota
Fusion:
 Nter: None
 Cter: None
Duplicate: in BACMK
Plasmid: None
Comments: The E.coli ykgEFG operon is a clear homolog of the B.subtilis lutABC operon,
 however it is not able of restoring L-lactate utilization to the B.subtilis mutant for
 lutABC operon (PubMed=19201793). Thus, ykgEFG operon may contribute to lactate catabolism in
 E.coli, but under conditions other than those tested, or alternatively, the ykgEFG operon
 may be responsible for the catabolism of a metabolite other than (but perhaps related to)
 lactate in E.coli.
 That's why the profile was not extended to Pseudomonadota and this family rule is currently
 restricted to Bacillota (in fact seed alignment only contains Bacillales), waiting for
 characterization in E.coli.
XX
# Revision 1.17 2023/06/01
//