AC   MF_02116;
DC   Protein; auto
TR   HAMAP; MF_02116; -; 1; level=0
XX
Names: FAPy_deform
XX
ID   ARFB
DE   RecName: Full=2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase;
DE            Short=FAPy deformylase;
DE            EC=3.5.1.102;
DE   AltName: Full=Formamide hydrolase;
GN   Name=arfB;
XX
CC   -!- FUNCTION: Catalyzes the hydrolysis of the formamide of 2-amino-5-
CC       formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy)
CC       to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate
CC       (APy).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-
CC         4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one
CC         5'-phosphate + formate + H(+); Xref=Rhea:RHEA:27282,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740,
CC         ChEBI:CHEBI:57258, ChEBI:CHEBI:59545; EC=3.5.1.102;
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC       Note=Requires one Fe(2+) ion for activity.;
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Requires an additional second metal ion that could be Fe(2+) or
CC       Zn(2+).;
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme F420 biosynthesis.
CC   -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the creatininase superfamily. FAPy deformylase
CC       family.
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DR   Pfam; PF02633; Creatininase; 1; trigger=no
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KW   Hydrolase
KW   Metal-binding
KW   Iron
KW   Zinc
XX
GO   GO:0008198; F:ferrous iron binding
GO   GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO   GO:0009231; P:riboflavin biosynthetic process
GO   GO:0052645; P:F420-0 metabolic process
XX
FT   From: ARFB_METJA (Q57580)
FT   BINDING         28
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT   Condition: E
FT   BINDING         30
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT   Condition: H
FT   BINDING         39
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         39
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         107
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT   Condition: H
XX
Size: 221-260;
Related: None;
Template: Q57580;
Scope:
 Archaea; Methanobacteria
 Archaea; Methanococci
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.10 2022/11/19
//