AC   MF_02126;
DC   Protein; auto
TR   HAMAP; MF_02126; -; 1; level=0
XX
Names: RF_methyltr_PrmC
XX
ID   PRMC
DE   RecName: Full=Release factor glutamine methyltransferase;
DE            Short=RF MTase;
DE            EC=2.1.1.297;
DE   AltName: Full=N5-glutamine methyltransferase PrmC;
DE   AltName: Full=Protein-(glutamine-N5) MTase PrmC;
DE   AltName: Full=Protein-glutamine N-methyltransferase PrmC;
GN   Name=prmC;
XX
CC   -!- FUNCTION: Methylates the class 1 translation termination release
CC       factors RF1/PrfA and RF2/PrfB on the glutamine residue of the
CC       universally conserved GGQ motif.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-
CC         methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release
CC         factor] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42896, Rhea:RHEA-
CC         COMP:10271, Rhea:RHEA-COMP:10272, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30011, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:61891; EC=2.1.1.297;
CC   -!- SIMILARITY: Belongs to the protein N5-glutamine methyltransferase
CC       family. PrmC subfamily.
XX
DR   Pfam; PF05175; MTS; 1; trigger=no
DR   NCBIfam; TIGR00536; HemK_fam; 1; trigger=no
DR   NCBIfam; TIGR03534; RF_mod_PrmC; 1; trigger=no
XX
KW   Methyltransferase
KW   S-adenosyl-L-methionine
KW   Transferase
XX
GO   GO:0036009; F:protein-glutamine N-methyltransferase activity
GO   GO:0018364; P:peptidyl-glutamine methylation
XX
FT   From: PRMC_ECOLI (P0ACC1)
FT   BINDING         117..121
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: G-x-G-x-G
FT   BINDING         183..186
FT                   /ligand="substrate"
FT   Condition: N-P-P-Y
FT   BINDING         140
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [DE]
FT   BINDING         168
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: [WF]
FT   BINDING         183
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: N
XX
Size: 270-354;
Related: None;
Template: P0ACC1; Q9WYV8; B0B9D1;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: MF_01057 (trmB)
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.10 2023/06/01
//