AC   MF_02130;
DC   Protein; auto
TR   HAMAP; MF_02130; -; 1; level=0
XX
Names: DHNA_arch
XX
ID   MPTD
DE   RecName: Full=Dihydroneopterin aldolase;
DE            Short=DHNA;
DE            EC=4.1.2.25;
DE   AltName: Full=7,8-dihydroneopterin aldolase;
GN   Name=mptD;
XX
CC   -!- FUNCTION: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to
CC       6-hydroxymethyl-7,8-dihydropterin (6-HMD).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin +
CC         glycolaldehyde; Xref=Rhea:RHEA:10540, ChEBI:CHEBI:17001,
CC         ChEBI:CHEBI:17071, ChEBI:CHEBI:44841; EC=4.1.2.25;
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
CC   -!- PATHWAY: Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin
CC       biosynthesis.
end case
case <OC:Halobacteria> or <OC:Methanosarcina>
CC   -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-
CC       4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-
CC       dihydroneopterin triphosphate: step 3/4.
end case
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SIMILARITY: Belongs to the archaeal dihydroneopterin aldolase family.
XX
DR   Pfam; PF04036; DUF372; 1; trigger=no
DR   Pfam; PF04038; DUF381; 1; trigger=no
XX
case <OC:Halobacteria> or <OC:Methanosarcina>
KW   Folate biosynthesis
end case
KW   Lyase
XX
GO   GO:0004150; F:dihydroneopterin aldolase activity
case <OC:Halobacteria> or <OC:Methanosarcina>
GO   GO:0046654; P:tetrahydrofolate biosynthetic process
end case
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
GO   GO:2001118; P:tetrahydromethanopterin biosynthetic process
end case
XX
FT   From: MPTD_METJA (Q57851)
FT   BINDING         25
FT                   /ligand="substrate"
FT   Condition: E
FT   BINDING         114
FT                   /ligand="substrate"
FT   Condition: M
XX
Size: 107-158;
Related: None;
Template: Q57851; Q8TX89; Q6L2J9;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.7 2022/05/14
//