AC   MF_02131;
DC   Protein; auto
TR   HAMAP; MF_02131; -; 1; level=0
XX
Names: HMPDK_arch
XX
ID   MPTE
DE   RecName: Full=6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase;
DE            Short=HPPK;
DE            EC=2.7.6.3;
DE   AltName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase;
DE   AltName: Full=6-hydroxymethyl-7,8-dihydropterin diphosphokinase;
DE            Short=6-HMPDK;
DE   AltName: Full=7,8-dihydro-6-hydroxymethylpterin diphosphokinase;
DE   AltName: Full=7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase;
DE            Short=PPPK;
GN   Name=mptE;
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CC   -!- FUNCTION: Catalyzes the transfer of diphosphate from ATP to 6-
CC       hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-
CC       7,8-dihydropterin diphosphate (6-HMDP).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-
CC         6-yl)methyl diphosphate + AMP + H(+); Xref=Rhea:RHEA:11412,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:44841,
CC         ChEBI:CHEBI:72950, ChEBI:CHEBI:456215; EC=2.7.6.3;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
CC   -!- PATHWAY: Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin
CC       biosynthesis.
end case
case <OC:Halobacteria> or <OC:Methanosarcina>
CC   -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-
CC       4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-
CC       dihydroneopterin triphosphate: step 4/4.
end case
CC   -!- SIMILARITY: Belongs to the archaeal 6-HMPDK family.
XX
DR   Pfam; PF01973; MAF_flag10; 1; trigger=no
XX
KW   ATP-binding
KW   Kinase
KW   Magnesium
KW   Nucleotide-binding
KW   Transferase
case <OC:Halobacteria> or <OC:Methanosarcina>
KW   Folate biosynthesis
end case
XX
GO   GO:0000287; F:magnesium ion binding
GO   GO:0003848; F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO   GO:0005524; F:ATP binding
case <OC:Halobacteria> or <OC:Methanosarcina>
GO   GO:0046654; P:tetrahydrofolate biosynthetic process
end case
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> or <OC:Archaeoglobi>
GO   GO:2001118; P:tetrahydromethanopterin biosynthetic process
end case
XX
FT   None
XX
Size: 183-273;
Related: None;
Template: Q59028; Q8U2A9;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2019/11/20
//