AC   MF_02132;
DC   Protein; auto
c?   <OC:Archaea>
TR   HAMAP; MF_02132; -; 1; level=0
XX
Names: AMP_phosphorylase
XX
ID   AMPPA
DE   RecName: Full=AMP phosphorylase;
DE            Short=AMPpase;
DE            EC=2.4.2.57;
DE   AltName: Full=Nucleoside monophosphate phosphorylase;
DE            Short=NMP phosphorylase;
XX
CC   -!- FUNCTION: Catalyzes the conversion of AMP and phosphate to adenine and
CC       ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward
CC       CMP and UMP in addition to AMP. Functions in an archaeal AMP
CC       degradation pathway, together with R15P isomerase and RubisCO.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate;
CC         Xref=Rhea:RHEA:36975, ChEBI:CHEBI:16708, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:68688, ChEBI:CHEBI:456215; EC=2.4.2.57;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=CMP + phosphate = alpha-D-ribose 1,5-bisphosphate + cytosine;
CC         Xref=Rhea:RHEA:36987, ChEBI:CHEBI:16040, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:60377, ChEBI:CHEBI:68688; EC=2.4.2.57;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=phosphate + UMP = alpha-D-ribose 1,5-bisphosphate + uracil;
CC         Xref=Rhea:RHEA:36991, ChEBI:CHEBI:17568, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57865, ChEBI:CHEBI:68688; EC=2.4.2.57;
CC   -!- SIMILARITY: Belongs to the thymidine/pyrimidine-nucleoside
CC       phosphorylase family. Type 2 subfamily.
XX
DR   Pfam; PF02885; Glycos_trans_3N; 1; trigger=no
DR   Pfam; PF00591; Glycos_transf_3; 1; trigger=no
DR   Pfam; PF07831; PYNP_C; 1; trigger=no
DR   NCBIfam; TIGR03327; AMP_phos; 1; trigger=no
DR   NCBIfam; TIGR02645; ARCH_P_rylase; 1; trigger=no
DR   PROSITE; PS00647; THYMID_PHOSPHORYLASE; 1; trigger=no
XX
KW   Glycosyltransferase
KW   Transferase
XX
GO   GO:0016208; F:AMP binding
GO   GO:0016763; F:pentosyltransferase activity
GO   GO:0006196; P:AMP catabolic process
XX
FT   From: AMPPA_THEKO (Q5JCX3)
FT   BINDING         194..199
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT   Condition: S-x-x-[IV]-T-[SG]
FT   ACT_SITE        256
FT                   /note="Proton donor"
FT   Condition: D
FT   BINDING         168
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT   Condition: G
FT   BINDING         203
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT   Condition: T
FT   BINDING         264
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT   Condition: S
FT   BINDING         288
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT   Condition: K
XX
Size: 500-516;
Related: None;
Template: Q5JCX3;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in ARCFU
Plasmid: None
Comments: None
XX
# Revision 1.13 2023/06/01
//