AC   MF_02208;
DC   Protein; auto
TR   HAMAP; MF_02208; -; 1; level=0
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Names: MurD2_subfam
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ID   MURD2
DE   RecName: Full=UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase;
DE            EC=6.3.2.53;
DE   AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-L-glutamate synthetase;
DE            Short=UDP-MurNAc-L-Ala-L-Glu synthetase;
GN   Name=murD2;
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CC   -!- FUNCTION: Cell wall formation. Catalyzes the addition of L-glutamate to
CC       the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine =
CC         ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-
CC         glutamate; Xref=Rhea:RHEA:58816, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:83898, ChEBI:CHEBI:142725, ChEBI:CHEBI:456216;
CC         EC=6.3.2.53;
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the MurCDEF family. MurD2 subfamily.
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DR   Pfam; PF08245; Mur_ligase_M; 1; trigger=no
DR   Pfam; PF02875; Mur_ligase_C; 1; trigger=no
DR   NCBIfam; TIGR01087; murD; 1; trigger=no
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KW   ATP-binding
KW   Cell cycle
KW   Cell division
KW   Cell shape
KW   Cell wall biogenesis/degradation
KW   Cytoplasm
KW   Ligase
KW   Nucleotide-binding
KW   Peptidoglycan synthesis
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GO   GO:0005524; F:ATP binding
GO   GO:0016881; F:acid-amino acid ligase activity
GO   GO:0009252; P:peptidoglycan biosynthetic process
GO   GO:0005737; C:cytoplasm
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FT   From: MURD2_XANOM (Q2P5V2)
FT   BINDING         122..128
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G-[TS]-[KN]-G-K-[ST]-T
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Size: 400-500;
Related: MF_00639;
Template: Q2P5V2; C4RJF7; A4X981;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.6 2023/06/01
//