AC   MF_02211;
DC   Protein; auto
TR   HAMAP; MF_02211; -; 1; level=0
XX
Names: MpaA_carboxypeptidase
XX
ID   MPAA
DE   RecName: Full=Murein peptide amidase A;
DE            EC=3.4.17.-;
DE   AltName: Full=Gamma-D-Glu-Dap amidase;
DE   AltName: Full=Zinc metallocarboxypeptidase MpaA;
GN   Name=mpaA;
XX
CC   -!- FUNCTION: Involved in muropeptide degradation. Catalyzes the hydrolysis
CC       of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide
CC       bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso-
CC       diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and
CC       Dap.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-alanyl-gamma-D-glutamyl-meso-diaminoheptanedioate = L-
CC         alanyl-D-glutamate + meso-2,6-diaminoheptanedioate;
CC         Xref=Rhea:RHEA:28398, ChEBI:CHEBI:15377, ChEBI:CHEBI:57791,
CC         ChEBI:CHEBI:61395, ChEBI:CHEBI:61401;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
end case
CC   -!- PATHWAY: Cell wall degradation; peptidoglycan degradation.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the peptidase M14 family.
XX
DR   Pfam; PF00246; Peptidase_M14; 1; trigger=no
DR   PROSITE; PS52035; PEPTIDASE_M14; 1; trigger=yes
XX
KW   Carboxypeptidase
KW   Cell wall biogenesis/degradation
KW   Cytoplasm
KW   Hydrolase
KW   Metalloprotease
KW   Protease
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
GO   GO:0061473; F:murein tripeptide carboxypeptidase activity
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
GO   GO:0009253; P:peptidoglycan catabolic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: MPAA_VIBC1 (A7N805)
FT   BINDING         60
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         63
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: E
FT   BINDING         168
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
XX
Size: 220-280;
Related: None;
Template: A7N805; P0ACV6;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.8 2023/08/16
//