AC   MF_02217;
DC   Protein; auto
TR   HAMAP; MF_02217; -; 1; level=0
XX
Names: TrmR_methyltr
XX
ID   TRMR
DE   RecName: Full=tRNA 5-hydroxyuridine methyltransferase;
DE            EC=2.1.1.-;
DE   AltName: Full=ho5U methyltransferase;
GN   Name=trmR;
XX
CC   -!- FUNCTION: Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form
CC       5-methoxyuridine (mo5U) at position 34 in tRNAs.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-
CC         methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:60524, Rhea:RHEA-COMP:13381, Rhea:RHEA-COMP:15591,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:136877, ChEBI:CHEBI:143860;
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. Cation-dependent O-methyltransferase family.
XX
DR   PROSITE; PS51682; SAM_OMT_I; 1; trigger=no
DR   Pfam; PF01596; Methyltransf_3; 1; trigger=no
XX
KW   Methyltransferase
KW   S-adenosyl-L-methionine
KW   Transferase
KW   tRNA processing
case <FTGroup:1>
KW   Magnesium
KW   Metal-binding
end case
XX
GO   GO:0016300; F:tRNA (uridine) methyltransferase activity
case <FTGroup:1>
GO   GO:0000287; F:magnesium ion binding
end case
GO   GO:0030488; P:tRNA methylation
XX
FT   From: TRMR_BACSU (O32036)
FT   BINDING         113..114
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: [DE]-A
FT   BINDING         133
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Optional; Group: 1; Condition: D
FT   BINDING         159
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Optional; Group: 1; Condition: D
FT   BINDING         160
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Optional; Group: 1; Condition: N
FT   BINDING         38
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: [MVIL]
FT   BINDING         68
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: S
FT   BINDING         85
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: [ED]
FT   BINDING         133
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: D
XX
Size: 190-270;
Related: None;
Template: O32036;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2023/10/13
//