AC   MF_02218;
DC   Protein; auto
TR   HAMAP; MF_02218; -; 1; level=0
XX
Names: GlcN_kinase
XX
ID   GLCNK
DE   RecName: Full=Glucosamine kinase;
DE            Short=GlcN kinase;
DE            Short=GlcNK;
DE            EC=2.7.1.8;
XX
CC   -!- FUNCTION: Catalyzes the ATP-dependent phosphorylation of D-glucosamine
CC       (GlcN) to D-glucosamine 6-phosphate. May be involved in the
CC       phosphorylation of acquired extracellular GlcN derived from the
CC       hydrolysis of chitosan, i.e., in the incorporation of exogenous GlcN
CC       into the bacterial GlcNAc metabolism.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-glucosamine = ADP + D-glucosamine 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:10948, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:58723, ChEBI:CHEBI:58725, ChEBI:CHEBI:456216; EC=2.7.1.8;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC       Note=Binds 2 Mg(2+) ions per subunit
CC   -!- SUBUNIT: Monomer.
CC   -!- SIMILARITY: Belongs to the actinobacterial glucosamine kinase family.
XX
KW   ATP-binding
KW   Carbohydrate metabolism
KW   Kinase
KW   Magnesium
KW   Metal-binding
KW   Nucleotide-binding
KW   Transferase
XX
GO   GO:0047931; F:glucosamine kinase activity
GO   GO:0000287; F:magnesium ion binding
GO   GO:0005975; P:carbohydrate metabolic process
XX
FT   From: GLCNK_STRJI (A0A1H7TQR5)
FT   BINDING         186..188
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: [AGST]-x-[LIV]
FT   MOTIF           405..420
FT                   /note="Substrate specificity determinant motif"
FT   Optional; Condition: Q-x(2)-R-E-x(2)-Y-A-x(3)-L-P-x-W
FT   BINDING         305
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: Q
FT   BINDING         317
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         317
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         319
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         133
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: K
FT   BINDING         193
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: D
FT   BINDING         300
FT                   /ligand="D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:58723"
FT   Optional; Condition: D
FT   BINDING         409
FT                   /ligand="D-glucosamine"
FT                   /ligand_id="ChEBI:CHEBI:58723"
FT   Optional; Condition: E
XX
Size: 300-440;
Related: None;
Template: A0A1H7TQR5; I7FJX8;
Scope:
 Bacteria; Actinomycetota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.5 2023/01/13
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