AC   MF_02222;
DC   Protein; auto
TR   HAMAP; MF_02222; -; 1; level=0
XX
Names: Homocitr_synth_fung_arch
XX
ID   HOSA
DE   RecName: Full=Homocitrate synthase;
DE            Short=HCS;
DE            EC=2.3.3.14;
XX
CC   -!- FUNCTION: Catalyzes the aldol-type condensation of 2-oxoglutarate with
CC       acetyl-CoA to yield homocitrate. Carries out the first step of the
CC       alpha-aminoadipate (AAA) lysine biosynthesis pathway.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + acetyl-CoA + H2O = (2R)-homocitrate + CoA +
CC         H(+); Xref=Rhea:RHEA:12929, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16810, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:58884; EC=2.3.3.14;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12930;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via AAA
CC       pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.
CC   -!- SIMILARITY: Belongs to the alpha-IPM synthase/homocitrate synthase
CC       family. Homocitrate synthase LYS20/LYS21 subfamily.
XX
DR   PROSITE; PS00815; AIPM_HOMOCIT_SYNTH_1; 1; trigger=no
DR   PROSITE; PS00816; AIPM_HOMOCIT_SYNTH_2; 1; trigger=no
DR   PROSITE; PS50991; PYR_CT; 1; trigger=yes
DR   Pfam; PF00682; HMGL-like; 1; trigger=no
DR   NCBIfam; TIGR02146; LysS_fung_arch; 1; trigger=no
XX
KW   Amino-acid biosynthesis
KW   Lysine biosynthesis
KW   Magnesium
KW   Manganese
KW   Metal-binding
KW   Transferase
XX
GO   GO:0004410; F:homocitrate synthase activity
GO   GO:0019878; P:lysine biosynthetic process via aminoadipic acid
XX
FT   From: HOSA_THET2 (O87198)
FT   ACT_SITE        292
FT                   /note="Proton acceptor"
FT   Condition: H
FT   BINDING         13
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: E
FT   BINDING         195
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: H
FT   BINDING         197
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: H
FT   BINDING         12
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT   Condition: R
FT   BINDING         72
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT   Condition: H
FT   BINDING         133
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT   Condition: R
FT   BINDING         166
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT   Condition: T
XX
Size: 340-500;
Related: None;
Template: O87198; Q4J989; Q971S5;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.5 2023/06/01
//