AC   MF_02224;
DC   Protein; auto
TR   HAMAP; MF_02224; -; 1; level=0
XX
Names: PPS
XX
ID   PPS
DE   RecName: Full=4-phosphopantoate--beta-alanine ligase;
DE            EC=6.3.2.36;
DE   AltName: Full=Phosphopantothenate synthetase;
DE            Short=PPS;
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CC   -!- FUNCTION: Catalyzes the condensation of (R)-4-phosphopantoate and beta-
CC       alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-
CC         phosphopantothenate + AMP + diphosphate + H(+); Xref=Rhea:RHEA:27930,
CC         ChEBI:CHEBI:10986, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57966, ChEBI:CHEBI:61294,
CC         ChEBI:CHEBI:456215; EC=6.3.2.36;
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the archaeal phosphopantothenate synthetase
CC       family.
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DR   Pfam; PF02006; PPS_PS; 1; trigger=no
DR   PIRSF; PIRSF004853; UCP004853; 1; trigger=no
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KW   ATP-binding
KW   Coenzyme A biosynthesis
KW   Ligase
KW   Nucleotide-binding
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GO   GO:0016881; F:acid-amino acid ligase activity
GO   GO:0015937; P:coenzyme A biosynthetic process
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FT   From: PPS_THEKO (Q5JIZ8)
FT   BINDING         181..183
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: D-[LI]-N
FT   BINDING         187..188
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: R-[ST]
FT   BINDING         199..200
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: N-[ILV]
FT   BINDING         17
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: R
FT   BINDING         39
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: R
XX
Size: 230-310;
Related: None;
Template: Q5JIZ8; Q2FUA9; B6YXQ1;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.4 2022/11/19
//