AC   MF_02225;
DC   Protein; auto
TR   HAMAP; MF_02225; -; 1; level=0
XX
Names: CoaBC
XX
ID   COABC
DE   RecName: Full=Coenzyme A biosynthesis bifunctional protein CoaBC;
DE   AltName: Full=DNA/pantothenate metabolism flavoprotein;
DE   AltName: Full=Phosphopantothenoylcysteine synthetase/decarboxylase;
DE            Short=PPCS-PPCDC;
DE   Includes:
DE     RecName: Full=Phosphopantothenoylcysteine decarboxylase;
DE              Short=PPC decarboxylase;
DE              Short=PPC-DC;
DE              EC=4.1.1.36;
DE     AltName: Full=CoaC;
DE   Includes:
DE     RecName: Full=Phosphopantothenate--cysteine ligase;
DE              EC=6.3.2.5;
DE     AltName: Full=CoaB;
DE     AltName: Full=Phosphopantothenoylcysteine synthetase;
DE              Short=PPC synthetase;
DE              Short=PPC-S;
GN   Name=coaBC;
XX
CC   -!- FUNCTION: Catalyzes two sequential steps in the biosynthesis of
CC       coenzyme A. In the first step cysteine is conjugated to 4'-
CC       phosphopantothenate to form 4-phosphopantothenoylcysteine. In the
CC       second step the latter compound is decarboxylated to form 4'-
CC       phosphopantotheine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-
CC         phosphopantetheine + CO2; Xref=Rhea:RHEA:16793, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:59458, ChEBI:CHEBI:61723; EC=4.1.1.36;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP +
CC         diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine;
CC         Xref=Rhea:RHEA:19397, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:35235, ChEBI:CHEBI:37563,
CC         ChEBI:CHEBI:59458, ChEBI:CHEBI:60377; EC=6.3.2.5;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC       Note=Binds 1 FMN per subunit.;
case <OC:Bacteria>
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-
CC       pantothenate: step 2/5.
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-
CC       pantothenate: step 3/5.
else case <OC:Archaea>
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis.
end case
CC   -!- SIMILARITY: In the N-terminal section; belongs to the HFCD (homo-
CC       oligomeric flavin containing Cys decarboxylase) superfamily.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the PPC synthetase
CC       family.
XX
DR   Pfam; PF04127; DFP; 1; trigger=no
DR   Pfam; PF02441; Flavoprotein; 1; trigger=no
DR   NCBIfam; TIGR00521; coaBC_dfp; 1; trigger=no
XX
KW   Decarboxylase
KW   Flavoprotein
KW   FMN
KW   Ligase
KW   Lyase
KW   Magnesium
KW   Metal-binding
KW   Multifunctional enzyme
XX
GO   GO:0010181; F:FMN binding
GO   GO:0004632; F:phosphopantothenate--cysteine ligase activity
GO   GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity
GO   GO:0015937; P:coenzyme A biosynthetic process
XX
FT   From: COABC_ECOLI (P0ABQ0)
FT   BINDING         273..275
FT                   /ligand="CTP"
FT                   /ligand_id="ChEBI:CHEBI:37563"
FT   Optional; Condition: G-C-A
FT   BINDING         308..311
FT                   /ligand="CTP"
FT                   /ligand_id="ChEBI:CHEBI:37563"
FT   Optional; Condition: P-D-[ILVM]-[VLI]
FT   REGION          Nter..190
FT                   /note="Phosphopantothenoylcysteine decarboxylase"
FT   REGION          191..Cter
FT                   /note="Phosphopantothenate--cysteine ligase"
FT   ACT_SITE        158
FT                   /note="Proton donor"
FT   Optional; Condition: C
FT   BINDING         279
FT                   /ligand="CTP"
FT                   /ligand_id="ChEBI:CHEBI:37563"
FT   Optional; Condition: D
FT   BINDING         289
FT                   /ligand="CTP"
FT                   /ligand_id="ChEBI:CHEBI:37563"
FT   Optional; Condition: K
FT   BINDING         327
FT                   /ligand="CTP"
FT                   /ligand_id="ChEBI:CHEBI:37563"
FT   Optional; Condition: F
FT   BINDING         341
FT                   /ligand="CTP"
FT                   /ligand_id="ChEBI:CHEBI:37563"
FT   Optional; Condition: K
FT   BINDING         345
FT                   /ligand="CTP"
FT                   /ligand_id="ChEBI:CHEBI:37563"
FT   Optional; Condition: K
XX
Size: 330-500;
Related: None;
Template: P0ABQ0; Q58323; Q5JF17;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2023/06/01
//