AC   MF_02228;
DC   Protein; auto
TR   HAMAP; MF_02228; -; 1; level=0
XX
Names: Sulfopropanediol_dehydrog
XX
ID   HPSN
DE   RecName: Full=Sulfopropanediol 3-dehydrogenase;
DE            EC=1.1.1.308;
DE   AltName: Full=2,3-dihydroxypropane-1-sulfonate 3-dehydrogenase (sulfolactate forming);
DE            Short=DHPS 3-dehydrogenase (sulfolactate forming);
GN   Name=hpsN;
XX
CC   -!- FUNCTION: Catalyzes the NAD-dependent oxidation of (R)-2,3-
CC       dihydroxypropane-1-sulfonate to (R)-3-sulfolactate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R)-3-sulfopropanediol + H2O + 2 NAD(+) = (2R)-3-sulfolactate
CC         + 3 H(+) + 2 NADH; Xref=Rhea:RHEA:28074, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:58738, ChEBI:CHEBI:60997; EC=1.1.1.308;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
end case
CC   -!- SIMILARITY: Belongs to the histidinol dehydrogenase family. HpsN
CC       subfamily.
XX
DR   PROSITE; PS00611; HISOL_DEHYDROGENASE; 1; trigger=no
DR   Pfam; PF00815; Histidinol_dh; 1; trigger=no
DR   PRINTS; PR00083; HOLDHDRGNASE; 1; trigger=no
DR   NCBIfam; TIGR00069; hisD; 1; trigger=no
DR   PIRSF; PIRSF000099; Histidinol_dh; 1; trigger=no
XX
KW   NAD
KW   Oxidoreductase
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
GO   GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
XX
FT   From: HPSN_CUPPJ (Q46N53)
FT   ACT_SITE        318
FT                   /note="Proton acceptor"
FT   Condition: E
FT   ACT_SITE        319
FT                   /note="Proton acceptor"
FT   Condition: H
FT   BINDING         248
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: [EQ]
FT   BINDING         251
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: H
FT   BINDING         352
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: D
FT   BINDING         411
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: H
FT   BINDING         118
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: Y
FT   BINDING         180
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: Q
FT   BINDING         203
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: N
XX
Size: 420-450;
Related: None;
Template: Q46N53;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: in CUPPJ
Comments: None
XX
# Revision 1.7 2023/06/01
//