AC   MF_02233;
DC   Protein; auto
TR   HAMAP; MF_02233; -; 1; level=0
XX
Names: UbiV
XX
ID   UBIV
DE   RecName: Full=Ubiquinone biosynthesis hydroxylase UbiV;
DE            EC=1.97.1.15;
DE   AltName: Full=2-(all-trans-polyprenyl)phenol 6-hydroxylase subunit UbiV;
GN   Name=ubiV;
XX
CC   -!- FUNCTION: Component of the UbiUV hydroxylase, which is involved in the
CC       oxygen-independent ubiquinone (coenzyme Q) biosynthesis. It catalyzes
CC       the three hydroxylation steps, using prephenate as the oxygen donor.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2-(all-trans-polyprenyl)phenol + prephenate + A + H(+) = a
CC         3-(all-trans-polyprenyl)benzene-1,2-diol + 3-phenylpyruvate + AH2 +
CC         CO2; Xref=Rhea:RHEA:81671, Rhea:RHEA-COMP:9516, Rhea:RHEA-COMP:9550,
CC         ChEBI:CHEBI:1269, ChEBI:CHEBI:13193, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:17499, ChEBI:CHEBI:18005,
CC         ChEBI:CHEBI:29934, ChEBI:CHEBI:62729; EC=1.97.1.15;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:81672;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2-methoxy-6-(all-trans-polyprenyl)phenol + prephenate + A +
CC         H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 3-
CC         phenylpyruvate + AH2 + CO2; Xref=Rhea:RHEA:81679, Rhea:RHEA-
CC         COMP:9551, Rhea:RHEA-COMP:10858, ChEBI:CHEBI:13193,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17499,
CC         ChEBI:CHEBI:18005, ChEBI:CHEBI:29934, ChEBI:CHEBI:62731,
CC         ChEBI:CHEBI:84166; EC=1.97.1.15;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:81680;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol
CC         + prephenate + A + H(+) = a 3-demethylubiquinol + 3-phenylpyruvate +
CC         AH2 + CO2; Xref=Rhea:RHEA:81687, Rhea:RHEA-COMP:10859, Rhea:RHEA-
CC         COMP:10914, ChEBI:CHEBI:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:17499, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934,
CC         ChEBI:CHEBI:84167, ChEBI:CHEBI:84422; EC=1.97.1.15;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:81688;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
end case
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC   -!- SUBUNIT: Forms a heterodimer with UbiU.
CC   -!- SIMILARITY: Belongs to the peptidase U32 family. UbiV subfamily.
XX
DR   PROSITE; PS01276; PEPTIDASE_U32; 1; trigger=no
DR   Pfam; PF01136; Peptidase_U32; 1; trigger=no
XX
case <FTGroup:1>
KW   4Fe-4S
KW   Iron
KW   Iron-sulfur
KW   Metal-binding
end case
KW   Ubiquinone biosynthesis
XX
case <FTGroup:1>
GO   GO:0051539; F:4 iron, 4 sulfur cluster binding
end case
GO   GO:0006744; P:ubiquinone biosynthetic process
XX
FT   From: UBIV_ECOLI (P45475)
FT   BINDING         39
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         180
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         193
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         197
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
XX
Size: 250-350;
Related: None;
Template: P45475;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Version: 8
# Last updated date: 2025-04-08
# Created date: 2019-10-01
//