AC   MF_02234;
DC   Protein; auto
TR   HAMAP; MF_02234; -; 1; level=0
XX
Names: AOTCase
XX
ID   AOTC
DE   RecName: Full=N-acetylornithine carbamoyltransferase;
DE            EC=2.1.3.9;
DE   AltName: Full=N-acetyl-L-ornithine transcarbamylase;
DE            Short=AOTCase;
DE            Short=Acetylornithine transcarbamylase;
GN   Name=argF';
XX
CC   -!- FUNCTION: Catalyzes the transfer of the carbamoyl group from carbamoyl
CC       phosphate to the delta-amino group of N(2)-acetyl-L-ornithine to
CC       produce N(2)-acetyl-L-citrulline. This is a step in an alternative
CC       arginine biosynthesis pathway.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=carbamoyl phosphate + N(2)-acetyl-L-ornithine = H(+) + N(2)-
CC         acetyl-L-citrulline + phosphate; Xref=Rhea:RHEA:18609,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57805,
CC         ChEBI:CHEBI:58228, ChEBI:CHEBI:58765; EC=2.1.3.9;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18610;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis.
CC   -!- SUBUNIT: Homotrimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase
CC       superfamily. AOTCase family.
XX
DR   Pfam; PF00185; OTCace; 1; trigger=no
DR   Pfam; PF02729; OTCace_N; 1; trigger=no
DR   PRINTS; PR00100; AOTCASE; 1; trigger=no
XX
KW   Amino-acid biosynthesis
KW   Arginine biosynthesis
KW   Cytoplasm
KW   Transferase
XX
GO   GO:0043857; F:N-acetylornithine carbamoyltransferase activity
GO   GO:0006526; P:arginine biosynthetic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: AOTC_XANCP (Q8P8J2)
FT   BINDING         49..52
FT                   /ligand="carbamoyl phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58228"
FT                   /ligand_note="ligand shared between two neighboring
FT                   subunits"
FT                   /note="in other chain"
FT   Condition: S-x-R-T
FT   BINDING         148..151
FT                   /ligand="carbamoyl phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58228"
FT                   /ligand_note="ligand shared between two neighboring
FT                   subunits"
FT                   /note="in other chain"
FT   Condition: H-P-C-Q
FT   BINDING         294..295
FT                   /ligand="carbamoyl phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58228"
FT                   /ligand_note="ligand shared between two neighboring
FT                   subunits"
FT                   /note="in other chain"
FT   Condition: C-L
FT   BINDING         77
FT                   /ligand="carbamoyl phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58228"
FT                   /ligand_note="ligand shared between two neighboring
FT                   subunits"
FT   Condition: W
FT   BINDING         112
FT                   /ligand="carbamoyl phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58228"
FT                   /ligand_note="ligand shared between two neighboring
FT                   subunits"
FT                   /note="in other chain"
FT   Condition: R
FT   BINDING         144
FT                   /ligand="N(2)-acetyl-L-ornithine"
FT                   /ligand_id="ChEBI:CHEBI:57805"
FT   Condition: E
FT   BINDING         252
FT                   /ligand="N(2)-acetyl-L-ornithine"
FT                   /ligand_id="ChEBI:CHEBI:57805"
FT   Condition: K
FT   BINDING         295
FT                   /ligand="N(2)-acetyl-L-ornithine"
FT                   /ligand_id="ChEBI:CHEBI:57805"
FT   Condition: L
FT   BINDING         322
FT                   /ligand="carbamoyl phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58228"
FT                   /ligand_note="ligand shared between two neighboring
FT                   subunits"
FT                   /note="in other chain"
FT   Condition: R
FT   SITE            92
FT                   /note="Key residue in conferring substrate specificity for
FT                   N-acetyl-L-ornithine versus N-succinyl-L-ornithine"
FT   Condition: E
FT   MOD_RES         302
FT                   /note="N6-carboxylysine"
FT   Condition: K
XX
Size: 310-370;
Related: None;
Template: Q8P8J2;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.7 2022/11/19
//