AC   MF_02236;
DC   Protein; auto
TR   HAMAP; MF_02236; -; 1; level=0
XX
Names: ACDase
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ID   ACDAS
DE   RecName: Full=N-acetyl-L-citrulline deacetylase;
DE            Short=ACDase;
DE            Short=Acetylcitrulline deacetylase;
DE            EC=3.5.1.-;
GN   Name=argE';
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CC   -!- FUNCTION: Catalyzes the deacetylation of N-acetyl-L-citrulline to
CC       produce L-citrulline. This is a step in an alternative arginine
CC       biosynthesis pathway.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N(2)-acetyl-L-citrulline = acetate + L-citrulline;
CC         Xref=Rhea:RHEA:61092, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:57743, ChEBI:CHEBI:58765;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61093;
CC   -!- COFACTOR:
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC       Note=Binds 1 Co(2+) ion per subunit.;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis.
CC   -!- SIMILARITY: Belongs to the peptidase M20A family. N-acetylcitrulline
CC       deacetylase subfamily.
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DR   Pfam; PF07687; M20_dimer; 1; trigger=no
DR   Pfam; PF01546; Peptidase_M20; 1; trigger=no
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KW   Amino-acid biosynthesis
KW   Arginine biosynthesis
KW   Cobalt
KW   Hydrolase
KW   Metal-binding
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GO   GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO   GO:0050897; F:cobalt ion binding
GO   GO:0006526; P:arginine biosynthetic process
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FT   From: ACDAS_XANCP (Q8P8J5)
FT   ACT_SITE        130
FT                   /note="Proton donor/acceptor"
FT   Condition: E
FT   BINDING         72
FT                   /ligand="Co(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48828"
FT   Condition: H
FT   BINDING         103
FT                   /ligand="Co(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48828"
FT   Condition: D
FT   BINDING         155
FT                   /ligand="Co(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48828"
FT   Condition: E
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Size: 335-420;
Related: None;
Template: Q8P8J5;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.4 2022/11/19
//