AC   MF_02237;
DC   Protein; auto
TR   HAMAP; MF_02237; -; 1; level=0
XX
Names: NSUN6
XX
ID   NSUN6
DE   RecName: Full=tRNA (cytosine(72)-C(5))-methyltransferase;
DE            Short=tRNA:m(5)C72 MTase;
DE            EC=2.1.1.-;
XX
CC   -!- FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that
CC       specifically methylates the C5 position of cytosine 72 in several
CC       tRNAs.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cytidine(72) in tRNA + S-adenosyl-L-methionine = 5-
CC         methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:61988, Rhea:RHEA-COMP:15996, Rhea:RHEA-COMP:15997,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74483, ChEBI:CHEBI:82748;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61989;
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RsmB/NOP family.
XX
DR   PROSITE; PS50890; PUA; 0-1; trigger=yes
DR   PROSITE; PS51686; SAM_MT_RSMB_NOP; 1; trigger=no
DR   Pfam; PF01189; Methyltr_RsmB-F; 1; trigger=no
DR   Pfam; PF01472; PUA; 0-1; trigger=no
DR   Pfam; PF17125; Methyltr_RsmF_N; 0-1; trigger=no
DR   NCBIfam; TIGR00446; nop2p; 0-1; trigger=no
DR   NCBIfam; TIGR00451; unchar_dom_2; 0-1; trigger=no
XX
KW   Methyltransferase
KW   RNA-binding
KW   S-adenosyl-L-methionine
KW   Transferase
XX
GO   GO:0016428; F:tRNA (cytidine-5-)-methyltransferase activity
GO   GO:0000049; F:tRNA binding
GO   GO:0006400; P:tRNA modification
XX
FT   From: NSUN6_PYRHO (O57712)
FT   BINDING         209..215
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: [ACSV]-[ACPS]-[AGP]-[PQ]-[AG]-[GINS]-K
FT   ACT_SITE        327
FT                   /note="Nucleophile"
FT   Condition: C
FT   BINDING         233
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: [DE]
FT   BINDING         238
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: [RK]
FT   BINDING         260
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: D
FT   BINDING         277
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: D
FT   BINDING         304
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Optional; Condition: Y
XX
Size: 320-420;
Related: None;
Template: O57712;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2023/10/13
//