AC   MF_02238;
DC   Protein; auto
TR   HAMAP; MF_02238; -; 1; level=0
XX
Names: DSD
XX
ID   DSD
DE   RecName: Full=3-dehydroshikimate dehydratase;
DE            Short=DSD;
DE            EC=4.2.1.118;
XX
CC   -!- FUNCTION: Catalyzes the conversion of 3-dehydroshikimate to
CC       protocatechuate (3,4-dihydroxybenzoate), a common intermediate of
CC       quinate and shikimate degradation pathways.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O;
CC         Xref=Rhea:RHEA:24848, ChEBI:CHEBI:15377, ChEBI:CHEBI:16630,
CC         ChEBI:CHEBI:36241; EC=4.2.1.118;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24849;
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC   -!- PATHWAY: Aromatic compound metabolism; 3,4-dihydroxybenzoate
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the bacterial two-domain DSD family.
XX
DR   PROSITE; PS51819; VOC; 2; trigger=yes
DR   Pfam; PF00903; Glyoxalase; 1; trigger=no
DR   Pfam; PF01261; AP_endonuc_2; 1; trigger=no
XX
KW   Lyase
KW   Metal-binding
XX
GO   GO:0046565; F:3-dehydroshikimate dehydratase activity
GO   GO:0046872; F:metal ion binding
XX
FT   From: DSD_PSEPK (Q88JU3)
FT   BINDING         134
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: E
FT   BINDING         165
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: D
FT   BINDING         191
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: Q
FT   BINDING         239
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: E
FT   BINDING         443
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Optional; Group: 2; Condition: H
FT   BINDING         521
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Optional; Group: 2; Condition: H
FT   BINDING         599
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Optional; Group: 2; Condition: E
XX
Size: 570-690;
Related: None;
Template: Q88JU3; Q9I6P6;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.3 2022/11/19
//