AC   MF_02239;
DC   Protein; auto
TR   HAMAP; MF_02239; -; 1; level=0
XX
Names: HemJ
XX
ID   HEMJ
DE   RecName: Full=Protoporphyrinogen IX oxidase;
DE            Short=PPO;
DE            EC=1.3.99.-;
XX
CC   -!- FUNCTION: Catalyzes the oxidation of protoporphyrinogen IX to
CC       protoporphyrin IX.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3 A + protoporphyrinogen IX = 3 AH2 + protoporphyrin IX;
CC         Xref=Rhea:RHEA:62000, ChEBI:CHEBI:13193, ChEBI:CHEBI:17499,
CC         ChEBI:CHEBI:57306, ChEBI:CHEBI:57307;
CC   -!- COFACTOR:
CC       Name=heme b; Xref=ChEBI:CHEBI:60344;
CC       Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.;
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the HemJ family.
XX
DR   Pfam; PF03653; UPF0093; 1; trigger=no
DR   PIRSF; PIRSF004638; UCP004638; 0-1; trigger=no
DR   NCBIfam; TIGR00701; TIGR00701; 1; trigger=no
DR   General; Transmembrane; -; 4-5; trigger=yes
XX
KW   Cell membrane
KW   Heme
KW   Iron
KW   Membrane
KW   Metal-binding
KW   Oxidoreductase
KW   Transmembrane
KW   Transmembrane helix
XX
GO   GO:0070818; F:protoporphyrinogen oxidase activity
GO   GO:0006779; P:porphyrin-containing compound biosynthetic process
GO   GO:0005886; C:plasma membrane
XX
FT   From: HEMJ_SYNY3 (P72793)
FT   BINDING         27
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
FT   BINDING         108
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: K
XX
Size: 145-210;
Related: None;
Template: P72793;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.5 2023/06/01
//