AC   MF_02241;
DC   Protein; auto
TR   HAMAP; MF_02241; -; 1; level=0
XX
Names: PIP_synthase
XX
ID   PIPS
DE   RecName: Full=Phosphatidylinositol phosphate synthase;
DE            Short=PIP synthase;
DE            EC=2.7.8.-;
DE   AltName: Full=CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase;
XX
CC   -!- FUNCTION: Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-
CC       inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a
CC       lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming
CC       phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of
CC       phosphatidylinositol (PI) which is an essential lipid required for cell
CC       wall formation.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1D-myo-inositol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol = a
CC         1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + CMP +
CC         H(+); Xref=Rhea:RHEA:60504, ChEBI:CHEBI:15378, ChEBI:CHEBI:58088,
CC         ChEBI:CHEBI:58332, ChEBI:CHEBI:58401, ChEBI:CHEBI:60377;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate
CC         + 1D-myo-inositol 3-phosphate = 1,2-di-(9Z-octadecenoyl)-sn-glycero-
CC         3-phospho-(1D-myo-inositol-3-phosphate) + CMP + H(+);
CC         Xref=Rhea:RHEA:61216, ChEBI:CHEBI:15378, ChEBI:CHEBI:58401,
CC         ChEBI:CHEBI:60377, ChEBI:CHEBI:85356, ChEBI:CHEBI:144472;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC       Note=Contains a di-nuclear catalytic Mg(2+) center.;
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylinositol phosphate
CC       biosynthesis.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I
CC       family.
XX
DR   PROSITE; PS00379; CDP_ALCOHOL_P_TRANSF; 1; trigger=no
DR   Pfam; PF01066; CDP-OH_P_transf; 1; trigger=no
DR   General; Transmembrane; -; 6; trigger=yes
XX
KW   Cell membrane
KW   Lipid biosynthesis
KW   Magnesium
KW   Membrane
KW   Metal-binding
KW   Phospholipid biosynthesis
KW   Phospholipid metabolism
KW   Transferase
KW   Transmembrane
KW   Transmembrane helix
XX
GO   GO:0000287; F:magnesium ion binding
GO   GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups
GO   GO:0008654; P:phospholipid biosynthetic process
GO   GO:0005886; C:plasma membrane
XX
FT   From: PIPS_MYCTU (P9WPG7)
FT   BINDING         31..34
FT                   /ligand="a CDP-1,2-diacyl-sn-glycerol"
FT                   /ligand_id="ChEBI:CHEBI:58332"
FT   Condition: [DN]-x-[VLIM]-T
FT   ACT_SITE        93
FT                   /note="Proton acceptor"
FT   Condition: D
FT   BINDING         68
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         68
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         71
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         89
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         89
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         93
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         72
FT                   /ligand="a CDP-1,2-diacyl-sn-glycerol"
FT                   /ligand_id="ChEBI:CHEBI:58332"
FT   Condition: G
FT   BINDING         76
FT                   /ligand="a CDP-1,2-diacyl-sn-glycerol"
FT                   /ligand_id="ChEBI:CHEBI:58332"
FT   Condition: R
FT   BINDING         82
FT                   /ligand="a CDP-1,2-diacyl-sn-glycerol"
FT                   /ligand_id="ChEBI:CHEBI:58332"
FT   Condition: [TS]
XX
Size: 190-290;
Related: None;
Template: P9WPG7; A0A0H3MFZ3; Q9F7Y9;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2022/11/19
//