AC   MF_02242;
DC   Protein; auto
TR   HAMAP; MF_02242; -; 1; level=0
XX
Names: AIP_synthase
XX
ID   AIPS
DE   RecName: Full=Archaetidylinositol phosphate synthase;
DE            Short=AIP synthase;
DE            EC=2.7.8.39;
XX
CC   -!- FUNCTION: Catalyzes the formation of archaetidylinositol phosphate
CC       (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-
CC       glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-
CC       phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an
CC       ether-type inositol phospholipid ubiquitously distributed in archaea
CC       membranes and essential for glycolipid biosynthesis in archaea.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1D-myo-inositol 3-phosphate + CDP-2,3-bis-O-(phytanyl)-sn-
CC         glycerol = CMP + H(+) + saturated 1-archaetidyl-1D-myo-inositol 3-
CC         phosphate; Xref=Rhea:RHEA:36823, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58401, ChEBI:CHEBI:60377, ChEBI:CHEBI:74004,
CC         ChEBI:CHEBI:74006; EC=2.7.8.39;
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC       Note=Binds 2 Mg(2+) or Mn(2+) ions per subunit.;
CC   -!- PATHWAY: Lipid metabolism; phospholipid metabolism.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I
CC       family.
XX
DR   PROSITE; PS00379; CDP_ALCOHOL_P_TRANSF; 1; trigger=no
DR   Pfam; PF01066; CDP-OH_P_transf; 1; trigger=no
DR   General; Transmembrane; -; 4-5; trigger=yes
XX
KW   Cell membrane
KW   Lipid biosynthesis
KW   Lipid metabolism
KW   Magnesium
KW   Manganese
KW   Membrane
KW   Metal-binding
KW   Phospholipid metabolism
KW   Transferase
KW   Transmembrane
KW   Transmembrane helix
XX
GO   GO:0000287; F:magnesium ion binding
GO   GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups
GO   GO:0008654; P:phospholipid biosynthetic process
GO   GO:0005886; C:plasma membrane
XX
FT   From: AIPS_METTH (O27726)
FT   ACT_SITE        93
FT                   /note="Proton acceptor"
FT   Condition: D
FT   BINDING         68
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         68
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         71
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         89
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         89
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         93
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT   Condition: D
XX
Size: 160-250;
Related: None;
Template: O27726; Q7LXU6; Q9YBS3;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.5 2022/11/19
//