AC   MF_02244;
DC   Protein; auto
TR   HAMAP; MF_02244; -; 1; level=0
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Names: Coproheme_decarbox_2
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ID   CHDC
DE   RecName: Full=Coproheme decarboxylase;
DE            EC=1.3.98.5;
DE   AltName: Full=Coproheme III oxidative decarboxylase;
DE   AltName: Full=Hydrogen peroxide-dependent heme synthase;
GN   Name=chdC;
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CC   -!- FUNCTION: Involved in coproporphyrin-dependent heme b biosynthesis.
CC       Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to
CC       heme b (protoheme IX), the last step of the pathway. The reaction
CC       occurs in a stepwise manner with a three-propionate intermediate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Fe-coproporphyrin III + 2 H(+) + 2 H2O2 = 2 CO2 + 4 H2O + heme
CC         b; Xref=Rhea:RHEA:56516, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16240, ChEBI:CHEBI:16526, ChEBI:CHEBI:60344,
CC         ChEBI:CHEBI:68438; EC=1.3.98.5;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56517;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Fe-coproporphyrin III + H(+) + H2O2 = CO2 + 2 H2O +
CC         harderoheme III; Xref=Rhea:RHEA:57940, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16240, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:68438, ChEBI:CHEBI:142463;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57941;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + H2O2 + harderoheme III = CO2 + 2 H2O + heme b;
CC         Xref=Rhea:RHEA:57944, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16240, ChEBI:CHEBI:16526, ChEBI:CHEBI:60344,
CC         ChEBI:CHEBI:142463;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:57945;
CC   -!- COFACTOR:
CC       Name=Fe-coproporphyrin III; Xref=ChEBI:CHEBI:68438;
CC       Note=Fe-coproporphyrin III acts as both substrate and redox cofactor;
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the ChdC family. Type 2 subfamily.
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DR   Pfam; PF06778; Chlor_dismutase; 1; trigger=no
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KW   Heme
KW   Heme biosynthesis
KW   Iron
KW   Metal-binding
KW   Oxidoreductase
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GO   GO:0016634; F:oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
GO   GO:0006785; P:heme B biosynthetic process
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FT   From: CHDC_MYCTU (P9WL45)
FT   ACT_SITE        133
FT   Condition: Y
FT   BINDING         156
FT                   /ligand="Fe-coproporphyrin III"
FT                   /ligand_id="ChEBI:CHEBI:68438"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT   Condition: H
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Size: 200-290;
Related: None;
Template: P9WL45; Q8Y5F1;
Scope:
 Bacteria; Actinomycetota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.4 2023/01/13
//