AC   MF_02246;
DC   Protein; auto
TR   HAMAP; MF_02246; -; 1; level=0
XX
Names: Gua_Ino_kinase
XX
ID   INGK
DE   RecName: Full=Guanosine-inosine kinase;
DE            EC=2.7.1.73;
GN   Name=gsk;
XX
CC   -!- FUNCTION: Catalyzes the phosphorylation of guanosine and inosine to GMP
CC       and IMP, respectively.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + guanosine = ADP + GMP + H(+); Xref=Rhea:RHEA:27710,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16750, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:58115, ChEBI:CHEBI:456216; EC=2.7.1.73;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + inosine = ADP + H(+) + IMP; Xref=Rhea:RHEA:21140,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17596, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:456216; EC=2.7.1.73;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from inosine: step 1/1.
CC   -!- PATHWAY: Purine metabolism; GMP biosynthesis via salvage pathway.
CC   -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
XX
DR   PROSITE; PS00583; PFKB_KINASES_1; 1; trigger=no
DR   PROSITE; PS00584; PFKB_KINASES_2; 1; trigger=no
DR   Pfam; PF00294; PfkB; 1; trigger=no
XX
KW   ATP-binding
KW   Kinase
KW   Magnesium
KW   Nucleotide-binding
KW   Purine salvage
KW   Transferase
XX
GO   GO:0005524; F:ATP binding
GO   GO:0008906; F:inosine kinase activity
GO   GO:0032263; P:GMP salvage
GO   GO:0032264; P:IMP salvage
XX
FT   From: INGK_ECOLI (P0AEW6)
FT   BINDING         40..45
FT                   /ligand="GMP"
FT                   /ligand_id="ChEBI:CHEBI:58115"
FT   Optional; Condition: D-[QE]-T-[LI]-V-D
FT   BINDING         93..97
FT                   /ligand="GMP"
FT                   /ligand_id="ChEBI:CHEBI:58115"
FT   Optional; Condition: G-[TA]-[IV]-[GA]-N
FT   BINDING         284..289
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: T-x-G-x-x-G
FT   BINDING         198
FT                   /ligand="GMP"
FT                   /ligand_id="ChEBI:CHEBI:58115"
FT   Optional; Condition: R
FT   BINDING         357
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: G
FT   BINDING         402
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: N
XX
Size: 400-480;
Related: None;
Template: P0AEW6;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.5 2023/01/26
//