AC   MF_02247;
DC   Protein; auto
TR   HAMAP; MF_02247; -; 1; level=0
XX
Names: Carbox_acid_reduct
XX
ID   CAR
DE   RecName: Full=Carboxylic acid reductase;
DE            Short=CAR;
DE            EC=1.2.1.-;
DE   AltName: Full=ATP/NADPH-dependent carboxylic acid reductase;
GN   Name=car;
XX
CC   -!- FUNCTION: Catalyzes the ATP- and NADPH-dependent reduction of
CC       carboxylic acids to the corresponding aldehydes.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a carboxylate + ATP + H(+) + NADPH = AMP + an aldehyde +
CC         diphosphate + NADP(+); Xref=Rhea:RHEA:50916, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:456215;
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC       Note=Binds 1 phosphopantetheine covalently.;
CC   -!- DOMAIN: The N-terminal domain likely catalyzes substrate activation by
CC       formation of an initial acyl-AMP intermediate, the central region
CC       contains the phosphopantetheine attachment site, and the C-terminal
CC       domain catalyzes the reduction by NADPH of the intermediate thioester
CC       formed from the attack of the phosphopantetheine thiol at the carbonyl
CC       carbon of acyl-AMP.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       Carboxylic acid reductase subfamily.
XX
DR   PROSITE; PS00455; AMP_BINDING; 1; trigger=no
DR   PROSITE; PS50075; CARRIER; 1; trigger=yes
DR   Pfam; PF00501; AMP-binding; 1; trigger=no
DR   Pfam; PF00550; PP-binding; 1; trigger=no
DR   Pfam; PF07993; NAD_binding_4; 1; trigger=no
DR   NCBIfam; TIGR01746; Thioester-redct; 1; trigger=no
XX
KW   ATP-binding
KW   NADP
KW   Nucleotide-binding
KW   Oxidoreductase
KW   Phosphopantetheine
KW   Phosphoprotein
XX
GO   GO:0005524; F:ATP binding
GO   GO:0050661; F:NADP binding
GO   GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO   GO:0031177; F:phosphopantetheine binding
XX
FT   From: CAR_SEGRC (E5XP76)
FT   BINDING         429..430
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT   Optional; Condition: [DE]-G
FT   BINDING         519..522
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT   Optional; Condition: Y-[VL]-D-R
FT   BINDING         801..804
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: [NT]-G-[FYW]-L
FT   BINDING         868..869
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: D-[FK]
FT   BINDING         894..896
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: [SP]-[GA]-A
FT   BINDING         315
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT   Optional; Condition: H
FT   BINDING         408
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT   Optional; Condition: [ST]
FT   BINDING         434
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT   Optional; Condition: T
FT   BINDING         507
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT   Optional; Condition: D
FT   BINDING         528
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT   Optional; Condition: K
FT   BINDING         629
FT                   /ligand="AMP"
FT                   /ligand_id="ChEBI:CHEBI:456215"
FT   Optional; Condition: K
FT   BINDING         828
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: R
FT   BINDING         838
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: R
FT   BINDING         934
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: S
FT   BINDING         970
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: Y
FT   BINDING         974
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: K
FT   BINDING         997
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: S
FT   MOD_RES         702
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT   Condition: S
XX
Size: 1000-1250;
Related: None;
Template: B2HN69; Q6RKB1; E5XP76;
Scope:
 Bacteria; Actinomycetota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.5 2023/06/01
//