AC   MF_02249;
DC   Protein; auto
TR   HAMAP; MF_02249; -; 1; level=0
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Names: BioZ
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ID   BIOZ
DE   RecName: Full=3-oxopimeloyl-[acyl-carrier-protein] synthase;
DE            Short=3-oxopimeloyl-[ACP] synthase;
DE            EC=2.3.1.-;
GN   Name=bioZ;
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CC   -!- FUNCTION: Involved in the formation of the biotin precursor pimeloyl-
CC       ACP. Catalyzes the condensation of glutaryl-CoA, an intermediate in
CC       lysine degradation, with malonyl-ACP to produce 3-oxopimeloyl-ACP.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an acyl-CoA + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 +
CC         CoA; Xref=Rhea:RHEA:44448, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9916,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:58342, ChEBI:CHEBI:78449, ChEBI:CHEBI:78776;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glutaryl-CoA + H(+) + malonyl-[ACP] = 3-oxo-6-carboxyhexanoyl-
CC         [ACP] + CO2 + CoA; Xref=Rhea:RHEA:67904, Rhea:RHEA-COMP:9623,
CC         Rhea:RHEA-COMP:17387, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57378, ChEBI:CHEBI:78449,
CC         ChEBI:CHEBI:176519;
CC   -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. BioZ family.
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DR   Pfam; PF08541; ACP_syn_III_C; 1; trigger=no
DR   Pfam; PF08545; ACP_syn_III; 1; trigger=no
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KW   Acyltransferase
KW   Biotin biosynthesis
KW   Transferase
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GO   GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups
GO   GO:0009102; P:biotin biosynthetic process
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FT   From: BIOZ_AGRFC (Q7CTU0)
FT   REGION          256..260
FT                   /note="ACP-binding"
FT   Condition: Q-A-N-x-R
FT   ACT_SITE        115
FT   Condition: C
FT   ACT_SITE        255
FT   Condition: H
FT   ACT_SITE        285
FT   Condition: N
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Size: 300-365;
Related: None;
Template: Q7CTU0; Q2YKB4; Q9EYU2; D0MCQ4;
Scope:
 Bacteria; Alphaproteobacteria
 Bacteria; Bacteroidota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.4 2022/10/06
//