AC MF_02250; DC Protein; auto TR HAMAP; MF_02250; -; 1; level=0 XX Names: GMPR_GuaB1 XX ID GUAB1 DE RecName: Full=GMP reductase; DE EC=1.7.1.7; DE AltName: Full=Guanosine 5'-monophosphate reductase; DE Short=GMPR; GN Name=guaB1; XX CC -!- FUNCTION: Involved in the purine-salvage pathway. Catalyzes the NADPH- CC dependent conversion of GMP to IMP. CC -!- CATALYTIC ACTIVITY: CC Reaction=IMP + NADP(+) + NH4(+) = GMP + 2 H(+) + NADPH; CC Xref=Rhea:RHEA:17185, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58053, ChEBI:CHEBI:58115, CC ChEBI:CHEBI:58349; EC=1.7.1.7; CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17187; CC -!- COFACTOR: CC Name=a monovalent cation; Xref=ChEBI:CHEBI:60242; CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway. CC -!- SIMILARITY: Belongs to the IMPDH/GMPR family. GuaB1 subfamily. XX DR PROSITE; PS51371; CBS; 2; trigger=yes DR Pfam; PF00478; IMPDH; 1; trigger=no DR Pfam; PF00571; CBS; 2; trigger=no DR PIRSF; PIRSF000130; IMPDH; 1; trigger=no DR NCBIfam; TIGR01303; IMP_DH_rel_1; 1; trigger=no XX KW NADP KW Oxidoreductase KW Purine salvage XX GO GO:0003920; F:GMP reductase activity GO GO:0006163; P:purine nucleotide metabolic process XX FT From: GUAB1_MYCS2 (A0QYE8) FT BINDING 245..247 FT /ligand="NADP(+)" FT /ligand_id="ChEBI:CHEBI:58349" FT Condition: D-T-A FT BINDING 295..297 FT /ligand="NADP(+)" FT /ligand_id="ChEBI:CHEBI:58349" FT Condition: [GN]-V-G FT ACT_SITE 302 FT /note="Thioimidate intermediate" FT Condition: C XX Size: 450-550; Related: None; Template: A0QYE8; P9WKI3; Scope: Bacteria; Actinomycetota Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.5 2023/06/01 //