AC MF_03004; DC Protein; auto TR HAMAP; MF_03004; -; 1; level=0 XX Names: eIF3e XX ID EIF3E case DE RecName: Full=Eukaryotic translation initiation factor 3 subunit E; DE Short=eIF3e; DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 6; DE AltName: Full=eIF-3 p48; else case DE RecName: Full=Eukaryotic translation initiation factor 3 subunit E; DE Short=eIF3e; else DE RecName: Full=Eukaryotic translation initiation factor 3 subunit E; DE Short=eIF3e; DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 6; end case case GN Name=EIF3E; Synonyms=EIF3S6, INT6; else case and not GN Name=EIF3E; Synonyms=EIF3S6; else case GN Name=eif-3.E; else case GN Name=eIF3e; Synonyms=eIF3-S6, Int6; else case GN Name=INT6; end case XX case CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3 CC (eIF-3) complex, which is required for several steps in the initiation CC of protein synthesis. The eIF-3 complex associates with the 40S CC ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- CC 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex CC (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC CC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also CC required for disassembly and recycling of post-termination ribosomal CC complexes and subsequently prevents premature joining of the 40S and CC 60S ribosomal subunits prior to initiation. The eIF-3 complex CC specifically targets and initiates translation of a subset of mRNAs CC involved in cell proliferation, including cell cycling, differentiation CC and apoptosis, and uses different modes of RNA stem-loop binding to CC exert either translational activation or repression. Required for CC nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to CC divert mRNAs from translation to the NMD pathway. May interact with CC MCM7 and EPAS1 and regulate the proteasome-mediated degradation of CC these proteins. else CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3 CC (eIF-3) complex, which is involved in protein synthesis of a CC specialized repertoire of mRNAs and, together with other initiation CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S CC ribosome. The eIF-3 complex specifically targets and initiates CC translation of a subset of mRNAs involved in cell proliferation. end case case CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3 CC (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, CC EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and CC EIF3M. The eIF-3 complex appears to include 3 stable modules: module A CC is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of CC EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, CC EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and CC EIF3H of module B, thereby linking the three modules. EIF3J is a labile CC subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex CC interacts with RPS6KB1 under conditions of nutrient depletion. CC Mitogenic stimulation leads to binding and activation of a complex CC composed of MTOR and RPTOR, leading to phosphorylation and release of CC RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, CC COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and CC UPF2. else case and not CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3 CC (eIF-3) complex, which is composed of 13 subunits: @gn(EIF3A), CC @gn(EIF3B), @gn(EIF3C), @gn(EIF3D), @gn(EIF3E), @gn(EIF3F), @gn(EIF3G), CC @gn(EIF3H), @gn(EIF3I), @gn(EIF3J), @gn(EIF3K), @gn(EIF3L) and CC @gn(EIF3M). else case CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3 CC (eIF-3) complex. The eIF-3 complex interacts with pix. else CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3 CC (eIF-3) complex. end case case CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, PML body. else case and not CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. else CC -!- SUBCELLULAR LOCATION: Cytoplasm. end case case CC -!- PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. end case CC -!- SIMILARITY: Belongs to the eIF-3 subunit E family. XX DR Pfam; PF01399; PCI; 1; trigger=no DR PROSITE; PS50250; PCI; 1; trigger=yes XX KW Cytoplasm KW Initiation factor KW Protein biosynthesis case KW Acetylation end case case KW Nucleus end case case KW Phosphoprotein end case XX GO GO:0003743; F:translation initiation factor activity GO GO:0001732; P:formation of cytoplasmic translation initiation complex GO GO:0002183; P:cytoplasmic translational initiation GO GO:0005737; C:cytoplasm case GO GO:0005634; C:nucleus end case GO GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e GO GO:0016282; C:eukaryotic 43S preinitiation complex GO GO:0033290; C:eukaryotic 48S preinitiation complex XX FT From: EIF3E_HUMAN (P60228) case FT INIT_MET 1 FT /note="Removed" FT Condition: M FT REGION 4..128 FT /note="Sufficient for interaction with EPAS1" FT REGION 9..195 FT /note="Sufficient for interaction with TRIM27" FT REGION 351..445 FT /note="Sufficient for interaction with MCM7" FT MOD_RES 2 FT /note="N-acetylalanine" FT Tag: acetyl; Condition: A end case XX Size: 357-601; Related: None; Template: P60228; P60229; O94513; Q6DRI1; Scope: Eukaryota Fusion: Nter: None Cter: None Duplicate: in DANRE, DROWI, XENLA Plasmid: None Comments: None XX # Revision 1.18 2019/11/20 //