AC MF_03008; DC Protein; auto TR HAMAP; MF_03008; -; 1; level=0 XX Names: eIF3i XX ID EIF3I case DE RecName: Full=Eukaryotic translation initiation factor 3 subunit I; DE Short=eIF3i; DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 2; DE AltName: Full=eIF-3-beta; DE AltName: Full=eIF3 p36; else case DE RecName: Full=Eukaryotic translation initiation factor 3 subunit I; DE Short=eIF3i; DE AltName: Full=Eukaryotic translation initiation factor 3 39 kDa subunit homolog; DE Short=eIF-3 39 kDa subunit homolog; else DE RecName: Full=Eukaryotic translation initiation factor 3 subunit I; DE Short=eIF3i; end case case GN Name=EIF3I; Synonyms=EIF3S2; else case GN Name=eIF3i; Synonyms=eif3-S2, Trip1; else case GN Name=eif-3.I; else case GN Name=TIF34; end case XX case CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3 CC (eIF-3) complex, which is required for several steps in the initiation CC of protein synthesis. The eIF-3 complex associates with the 40S CC ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- CC 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex CC (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC CC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also CC required for disassembly and recycling of post-termination ribosomal CC complexes and subsequently prevents premature joining of the 40S and CC 60S ribosomal subunits prior to initiation. The eIF-3 complex CC specifically targets and initiates translation of a subset of mRNAs CC involved in cell proliferation, including cell cycling, differentiation CC and apoptosis, and uses different modes of RNA stem-loop binding to CC exert either translational activation or repression. else CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3 CC (eIF-3) complex, which is involved in protein synthesis of a CC specialized repertoire of mRNAs and, together with other initiation CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S CC ribosome. The eIF-3 complex specifically targets and initiates CC translation of a subset of mRNAs involved in cell proliferation. end case case CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3 CC (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, CC EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and CC EIF3M. The eIF-3 complex appears to include 3 stable modules: module A CC is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of CC EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, CC EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and CC EIF3H of module B, thereby linking the three modules. EIF3J is a labile CC subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex CC interacts with RPS6KB1 under conditions of nutrient depletion. CC Mitogenic stimulation leads to binding and activation of a complex CC composed of MTOR and RPTOR, leading to phosphorylation and release of CC RPS6KB1 and binding of EIF4B to eIF-3. else case and not CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3 CC (eIF-3) complex, which is composed of 13 subunits: @gn(EIF3A), CC @gn(EIF3B), @gn(EIF3C), @gn(EIF3D), @gn(EIF3E), @gn(EIF3F), @gn(EIF3G), CC @gn(EIF3H), @gn(EIF3I), @gn(EIF3J), @gn(EIF3K), @gn(EIF3L) and CC @gn(EIF3M). else case CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3 CC (eIF-3) complex. The eIF-3 complex interacts with pix. else CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3 CC (eIF-3) complex. end case CC -!- SUBCELLULAR LOCATION: Cytoplasm. case CC -!- PTM: Phosphorylated by TGF-beta type II receptor. end case CC -!- SIMILARITY: Belongs to the eIF-3 subunit I family. XX DR PROSITE; PS00678; WD_REPEATS_1; 1; trigger=no DR PROSITE; PS50082; WD_REPEATS_2; 4; trigger=no DR PROSITE; PS50294; WD_REPEATS_REGION; 2; trigger=no DR Pfam; PF00400; WD40; 4; trigger=no DR REP; Repeat_WD40; WD40; 5-7; trigger=yes XX KW Cytoplasm KW Initiation factor KW Protein biosynthesis case KW Phosphoprotein end case XX GO GO:0003743; F:translation initiation factor activity GO GO:0001732; P:formation of cytoplasmic translation initiation complex GO GO:0002183; P:cytoplasmic translational initiation GO GO:0005737; C:cytoplasm GO GO:0005852; C:eukaryotic translation initiation factor 3 complex GO GO:0016282; C:eukaryotic 43S preinitiation complex GO GO:0033290; C:eukaryotic 48S preinitiation complex XX FT None XX Size: 299-356; Related: None; Template: Q13347; Q9QZD9; P79083; P40217; Scope: Eukaryota Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.13 2019/11/20 //