AC   MF_03012;
DC   Protein; auto
TR   HAMAP; MF_03012; -; 1; level=0
XX
Names: eIF3m
XX
ID   EIF3M
case <OC:Caenorhabditis>
DE   RecName: Full=COP9/Signalosome and eIF3 complex-shared subunit 1;
DE   AltName: Full=COP9 signalosome complex subunit 7;
DE            Short=Signalosome subunit 7;
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit M;
DE            Short=eIF3m;
else case <OC:Drosophilidae>
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit M;
DE            Short=eIF3m;
DE   AltName: Full=Transport and Golgi organization protein 7;
DE            Short=Tango-7;
else
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit M;
DE            Short=eIF3m;
end case
case <OC:Vertebrata>
GN   Name=EIF3M;
else case <OC:Caenorhabditis>
GN   Name=cif-1; Synonyms=csn-7, eif-3.M;
else case <OC:Drosophilidae>
GN   Name=eIF3m; Synonyms=Tango7;
end case
XX
case <OC:Mammalia>
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is required for several steps in the initiation
CC       of protein synthesis. The eIF-3 complex associates with the 40S
CC       ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-
CC       2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex
CC       (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC
CC       and scanning of the mRNA for AUG recognition. The eIF-3 complex is also
CC       required for disassembly and recycling of post-termination ribosomal
CC       complexes and subsequently prevents premature joining of the 40S and
CC       60S ribosomal subunits prior to initiation. The eIF-3 complex
CC       specifically targets and initiates translation of a subset of mRNAs
CC       involved in cell proliferation, including cell cycling, differentiation
CC       and apoptosis, and uses different modes of RNA stem-loop binding to
CC       exert either translational activation or repression.
else case <OC:Caenorhabditis>
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       Component of the COP9 signalosome complex (CSN), a complex involved in
CC       various cellular and developmental processes. The CSN complex is an
CC       essential regulator of the ubiquitin (Ubl) conjugation pathway by
CC       mediating the deneddylation of the cullin subunits of the SCF-type E3
CC       ligase complexes, leading to decrease the Ubl ligase activity of SCF.
CC       The CSN complex plays an essential role in embryogenesis and oogenesis
CC       and is required to regulate microtubule stability in the early embryo.
CC       Mediates mei-1 targeting for degradation at the meiosis to mitosis
CC       transition via deneddylation of cul-3.
else
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
end case
case <OC:Mammalia>
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C,
CC       EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and
CC       EIF3M. The eIF-3 complex appears to include 3 stable modules: module A
CC       is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of
CC       EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D,
CC       EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and
CC       EIF3H of module B, thereby linking the three modules. EIF3J is a labile
CC       subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex
CC       interacts with RPS6KB1 under conditions of nutrient depletion.
CC       Mitogenic stimulation leads to binding and activation of a complex
CC       composed of MTOR and RPTOR, leading to phosphorylation and release of
CC       RPS6KB1 and binding of EIF4B to eIF-3.
else case <OC:Vertebrata> and not <OC:Mammalia>
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is composed of 13 subunits: @gn(EIF3A),
CC       @gn(EIF3B), @gn(EIF3C), @gn(EIF3D), @gn(EIF3E), @gn(EIF3F), @gn(EIF3G),
CC       @gn(EIF3H), @gn(EIF3I), @gn(EIF3J), @gn(EIF3K), @gn(EIF3L) and
CC       @gn(EIF3M).
else case <OC:Drosophilidae>
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
else case <OC:Caenorhabditis>
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. Within the eIF-3 complex, interacts directly with eif-
CC       3.F. Component of the CSN complex, composed of csn-1, csn-2, csn-3,
CC       csn-4, csn-5, csn-6 and csn-7. Within the CSN complex, interacts
CC       directly with csn-1 and csn-4.
else
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex.
end case
case <OC:Drosophilidae>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus.
else
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
end case
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit M family.
XX
DR   Pfam; PF01399; PCI; 1; trigger=no
DR   PROSITE; PS50250; PCI; 1; trigger=yes
XX
KW   Cytoplasm
KW   Initiation factor
KW   Protein biosynthesis
case <OC:Drosophilidae>
KW   Golgi apparatus
end case
case <OC:Caenorhabditis>
KW   Developmental protein
KW   Differentiation
KW   Oogenesis
KW   Signalosome
end case
case <FTTag:acetyl>
KW   Acetylation
end case
XX
GO   GO:0003743; F:translation initiation factor activity
case <OC:Caenorhabditis>
GO   GO:0000338; P:protein deneddylation
end case
GO   GO:0001732; P:formation of cytoplasmic translation initiation complex
GO   GO:0002183; P:cytoplasmic translational initiation
GO   GO:0005737; C:cytoplasm
case <OC:Drosophilidae>
GO   GO:0005794; C:Golgi apparatus
end case
GO   GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m
case <OC:Caenorhabditis>
GO   GO:0008180; C:COP9 signalosome
end case
GO   GO:0016282; C:eukaryotic 43S preinitiation complex
GO   GO:0033290; C:eukaryotic 48S preinitiation complex
XX
FT   From: EIF3M_HUMAN (Q7L2H7)
case <OC:Mammalia>
FT   INIT_MET        1
FT                   /note="Removed"
FT   Condition: M
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT   Tag: acetyl; Condition: S
end case
XX
Size: 373-555;
Related: None;
Template: Q7L2H7; Q94261; Q7JVI3; Q09722;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.16 2019/11/20
//