AC   MF_03014;
DC   Protein; auto
TR   HAMAP; MF_03014; -; 1; level=0
XX
Names: KFase
XX
ID   KFA
DE   RecName: Full=Kynurenine formamidase;
DE            Short=KFase;
DE            Short=KFA;
DE            EC=3.5.1.9;
DE   AltName: Full=Arylformamidase;
DE   AltName: Full=N-formylkynurenine formamidase;
DE            Short=FKF;
case <OC:Vertebrata>
GN   Name=AFMID;
else case <OC:Saccharomycotina>
GN   Name=BNA7;
end case
XX
case <OC:Vertebrata> or <OC:Fungi>
CC   -!- FUNCTION: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-
CC       kynurenine, the second step in the kynurenine pathway of tryptophan
CC       degradation. Kynurenine may be further oxidized to nicotinic acid,
CC       NAD(H) and NADP(H). Required for elimination of toxic metabolites.
else
CC   -!- FUNCTION: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-
CC       kynurenine, the second step in the kynurenine pathway of tryptophan
CC       degradation. Required for elimination of toxic metabolites.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N-formyl-L-kynurenine = formate + H(+) + L-kynurenine;
CC         Xref=Rhea:RHEA:13009, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15740, ChEBI:CHEBI:57959, ChEBI:CHEBI:58629; EC=3.5.1.9;
CC   -!- PATHWAY: Amino-acid degradation; L-tryptophan degradation via
CC       kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
case <OC:Mammalia>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus. Note=Predominantly
CC       cytosolic. Some fraction is nuclear.
else case <OC:Vertebrata> and not <OC:Mammalia>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus.
end case
CC   -!- SUBUNIT: Homodimer.
case <FTTag:HGGXW>
CC   -!- DOMAIN: The main chain amide nitrogen atoms of the second glycine and
CC       its adjacent residue in the HGGXW motif define the oxyanion hole, and
CC       stabilize the oxyanion that forms during the nucleophilic attack by the
CC       catalytic serine during substrate cleavage.
end case
CC   -!- SIMILARITY: Belongs to the kynurenine formamidase family.
XX
case <OC:Vertebrata>
KW   Cytoplasm
KW   Nucleus
end case
KW   Hydrolase
KW   Tryptophan catabolism
XX
GO   GO:0004061; F:arylformamidase activity
GO   GO:0006569; P:tryptophan catabolic process
case <OC:Vertebrata> or <OC:Fungi>
GO   GO:0034354; P:'de novo' NAD biosynthetic process from tryptophan
end case
case <OC:Vertebrata>
GO   GO:0005634; C:nucleus
GO   GO:0005737; C:cytoplasm
end case
XX
FT   From: KFA_DROME (Q9VMC9)
FT   MOTIF           86..90
FT                   /note="HGGXW"
FT   Tag: HGGXW; Condition: H-G-G-x-W
FT   ACT_SITE        157
FT                   /note="Nucleophile"
FT   Condition: S
FT   ACT_SITE        244
FT   Condition: [DE]
FT   ACT_SITE        276
FT   Condition: H
XX
Size: 241-399;
Related: None;
Template: Q9VMC9; Q8K4H1; Q04066;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.10 2019/11/20
//