AC MF_03016; DC Protein; auto TR HAMAP; MF_03016; -; 1; level=0 XX Names: Ribosomal_S2_laminin_receptor XX ID RSSA DE RecName: Full=Small ribosomal subunit protein uS2; DE AltName: Full=37 kDa laminin receptor precursor; DE Short=37LRP; DE AltName: Full=37/67 kDa laminin receptor; DE Short=LRP/LR; DE AltName: Full=67 kDa laminin receptor; DE Short=67LR; DE AltName: Full=Laminin receptor 1; DE Short=LamR; DE AltName: Full=Laminin-binding protein precursor p40; DE Short=LBP/p40; GN Name=RPSA; XX case CC -!- FUNCTION: Required for the assembly and/or stability of the 40S CC ribosomal subunit. Required for the processing of the 20S rRNA- CC precursor to mature 18S rRNA in a late step of the maturation of 40S CC ribosomal subunits. Also functions as a cell surface receptor for CC laminin. Plays a role in cell adhesion to the basement membrane and in CC the consequent activation of signaling transduction pathways. May play CC a role in cell fate determination and tissue morphogenesis. Also acts CC as a receptor for several other ligands, including the pathogenic prion CC protein, viruses, and bacteria. Acts as a @gn(PPP1R16B)-dependent CC substrate of @gn(PPP1CA). CC -!- SUBUNIT: Monomer (37LRP) and homodimer (67LR). Component of the small CC ribosomal subunit. Mature ribosomes consist of a small (40S) and a CC large (60S) subunit. The 40S subunit contains about 33 different CC proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 CC different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts CC with @gn(RPS21). Interacts with several laminins including at least CC @gn(LAMB1). Interacts with @gn(MDK). The mature dimeric form interacts CC with @gn(PPP1R16B) (via its fourth ankyrin repeat). Interacts with CC @gn(PPP1CA) only in the presence of @gn(PPP1R16B). CC -!- SUBCELLULAR LOCATION: Cell membrane. Cytoplasm. Nucleus. Note=67LR is CC found at the surface of the plasma membrane, with its C-terminal CC laminin-binding domain accessible to extracellular ligands. 37LRP is CC found at the cell surface, in the cytoplasm and in the nucleus. Co- CC localizes with @gn(PPP1R16B) in the cell membrane. else case and not CC -!- FUNCTION: Required for the assembly and/or stability of the 40S CC ribosomal subunit. Required for the processing of the 20S rRNA- CC precursor to mature 18S rRNA in a late step of the maturation of 40S CC ribosomal subunits. Also functions as a cell surface receptor for CC laminin. Plays a role in cell adhesion to the basement membrane and in CC the consequent activation of signaling transduction pathways. May play CC a role in cell fate determination and tissue morphogenesis. CC -!- SUBUNIT: Monomer (37LRP) and homodimer (67LR). Component of the small CC ribosomal subunit. Mature ribosomes consist of a small (40S) and a CC large (60S) subunit. The 40S subunit contains about 33 different CC proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 CC different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts CC with @gn(RPS21). Interacts with several laminins including at least CC @gn(LAMB1). Interacts with @gn(MDK). CC -!- SUBCELLULAR LOCATION: Cell membrane. Cytoplasm. Nucleus. Note=67LR is CC found at the surface of the plasma membrane, with its C-terminal CC laminin-binding domain accessible to extracellular ligands. 37LRP is CC found at the cell surface, in the cytoplasm and in the nucleus. end case CC -!- PTM: Acylated. Acylation may be a prerequisite for conversion of the CC monomeric 37 kDa laminin receptor precursor (37LRP) to the mature CC dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for CC membrane association. CC -!- PTM: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by CC stromelysin-3 may be a mechanism to alter cell-extracellular matrix CC interactions. CC -!- MISCELLANEOUS: This protein appears to have acquired a second function CC as a laminin receptor specifically in the vertebrate lineage. CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS2 family. XX DR PROSITE; PS00962; RIBOSOMAL_S2_1; 1; trigger=no DR PROSITE; PS00963; RIBOSOMAL_S2_2; 1; trigger=no DR Pfam; PF00318; Ribosomal_S2; 1; trigger=no DR PRINTS; PR00395; RIBOSOMALS2; 1; trigger=no DR NCBIfam; TIGR01012; Sa_S2_E_A; 1; trigger=no XX case KW Acetylation end case KW Cell membrane KW Membrane KW Receptor KW Nucleus case KW Repeat end case KW Cytoplasm KW Ribonucleoprotein KW Ribosomal protein XX GO GO:0043236; F:laminin binding GO GO:0005055; F:laminin receptor activity GO GO:0007155; P:cell adhesion GO GO:0022627; C:cytosolic small ribosomal subunit GO GO:0003735; F:structural constituent of ribosome GO GO:0000028; P:ribosomal small subunit assembly GO GO:0006412; P:translation XX FT From: RSSA_HUMAN (P08865) FT INIT_MET 1 FT /note="Removed" FT Condition: M FT MOD_RES 2 FT /note="N-acetylserine" FT Tag: acetyl; Condition: S FT REPEAT 230..232 FT /note="[DE]-W-[ST] 1" FT Group: 1; Condition: [DE]-W-[ST] FT REPEAT 247..249 FT /note="[DE]-W-[ST] 2" FT Group: 1; Condition: [DE]-W-[ST] FT REPEAT 266..268 FT /note="[DE]-W-[ST] 3" FT Group: 1; Condition: [DE]-W-[ST] FT REPEAT 275..277 FT /note="[DE]-W-[ST] 4" FT Group: 1; Condition: [DE]-W-[ST] FT REPEAT 293..295 FT /note="[DE]-W-[ST] 5" FT Group: 1; Condition: [DE]-W-[ST] case FT REGION 54..113 FT /note="Interaction with @gn(PPP1R16B)" end case FT REGION 161..180 FT /note="Laminin-binding" FT REGION 205..229 FT /note="Laminin-binding" FT REGION 242..295 FT /note="Laminin-binding" FT From: RSSA_XENLA (Q3ZM03) FT SITE 115..116 FT /note="Cleavage; by ST3; site 1" FT Condition: A-F FT SITE 133..134 FT /note="Cleavage; by ST3; site 2" FT Condition: P-[ILV] XX Size: 295-317; Related: MF_03015; Template: P08865; P14206; Q3ZM03; P38982; Scope: Eukaryota; Vertebrata Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.9 2023/06/01 //