AC MF_03020; DC Protein; auto c? TR HAMAP; MF_01972; -; 1; level=0 XX Names: T23O_euk XX ID T23O case DE RecName: Full=Tryptophan 2,3-dioxygenase; DE Short=TDO; DE EC=1.13.11.11; DE AltName: Full=Protein vermilion; DE AltName: Full=Tryptamin 2,3-dioxygenase; DE AltName: Full=Tryptophan oxygenase; DE Short=TO; DE Short=TRPO; DE AltName: Full=Tryptophan pyrrolase; DE AltName: Full=Tryptophanase; else DE RecName: Full=Tryptophan 2,3-dioxygenase; DE Short=TDO; DE EC=1.13.11.11; DE AltName: Full=Tryptamin 2,3-dioxygenase; DE AltName: Full=Tryptophan oxygenase; DE Short=TO; DE Short=TRPO; DE AltName: Full=Tryptophan pyrrolase; DE AltName: Full=Tryptophanase; end case case GN Name=TDO2; else case GN Name=tdo; else case GN Name=v; end case XX CC -!- FUNCTION: Heme-dependent dioxygenase that catalyzes the oxidative CC cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- CC tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage CC of the indole moiety. CC -!- CATALYTIC ACTIVITY: CC Reaction=L-tryptophan + O2 = N-formyl-L-kynurenine; CC Xref=Rhea:RHEA:24536, ChEBI:CHEBI:15379, ChEBI:CHEBI:57912, CC ChEBI:CHEBI:58629; EC=1.13.11.11; CC -!- COFACTOR: CC Name=heme; Xref=ChEBI:CHEBI:30413; CC Note=Binds 1 heme group per subunit.; CC -!- PATHWAY: Amino-acid degradation; L-tryptophan degradation via CC kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. case CC -!- PATHWAY: Pigment biosynthesis; ommochrome biosynthesis. end case CC -!- SUBUNIT: Homotetramer. Dimer of dimers. CC -!- SIMILARITY: Belongs to the tryptophan 2,3-dioxygenase family. XX DR Pfam; PF03301; Trp_dioxygenase; 1; trigger=no DR PROSITE; PS50312; ASP_RICH; 0-unlimited; trigger=strict DR PROSITE; PS50313; GLU_RICH; 0-unlimited; trigger=strict DR PROSITE; PS50318; LYS_RICH; 0-unlimited; trigger=strict DR PROSITE; PS50323; ARG_RICH; 0-unlimited; trigger=strict XX KW Dioxygenase KW Heme KW Iron KW Metal-binding KW Oxidoreductase KW Tryptophan catabolism XX GO GO:0004833; F:tryptophan 2,3-dioxygenase activity GO GO:0020037; F:heme binding GO GO:0006569; P:tryptophan catabolic process XX FT From: T23O_HUMAN (Q8PDA8) FT BINDING 72..76 FT /ligand="substrate" FT Condition: F-[IV]-[IVT]-[IVQT]-H FT BINDING 328 FT /ligand="heme" FT /ligand_id="ChEBI:CHEBI:30413" FT /ligand_part="Fe" FT /ligand_part_id="ChEBI:CHEBI:18248" FT /note="axial binding residue" FT Condition: H FT BINDING 144 FT /ligand="substrate" FT Condition: R FT BINDING 342 FT /ligand="substrate" FT Condition: T XX Size: 260-412; Related: None; Template: P48775; P48776; P21643; Q17P71; P20351; Scope: Eukaryota Fusion: Nter: None Cter: None Duplicate: in DANRE Plasmid: None Comments: None XX # Revision 1.16 2022/11/19 //