AC   MF_03022;
DC   Protein; auto
TR   HAMAP; MF_03022; -; 1; level=0
XX
Names: Katanin_p80_B1
XX
ID   KTNB1
case <OC:Metazoa>
DE   RecName: Full=Katanin p80 WD40 repeat-containing subunit B1;
DE            Short=Katanin p80 subunit B1;
DE   AltName: Full=p80 katanin;
GN   Name=KATNB1;
else
DE   RecName: Full=Katanin p80 WD40 repeat-containing subunit B1 homolog;
end case
XX
case <OC:Mammalia>
CC   -!- FUNCTION: Participates in a complex which severs microtubules in an
CC       ATP-dependent manner. May act to target the enzymatic subunit of this
CC       complex to sites of action such as the centrosome. Microtubule severing
CC       may promote rapid reorganization of cellular microtubule arrays and the
CC       release of microtubules from the centrosome following nucleation.
CC       Microtubule release from the mitotic spindle poles may allow
CC       depolymerization of the microtubule end proximal to the spindle pole,
CC       leading to poleward microtubule flux and poleward motion of chromosome.
CC       Microtubule release within the cell body of neurons may be required for
CC       their transport into neuronal processes by microtubule-dependent motor
CC       proteins. This transport is required for axonal growth.
else case <OC:Metazoa>
CC   -!- FUNCTION: Participates in a complex which severs microtubules in an
CC       ATP-dependent manner. May act to target the enzymatic subunit of this
CC       complex to sites of action such as the centrosome. Microtubule severing
CC       may promote rapid reorganization of cellular microtubule arrays and the
CC       release of microtubules from the centrosome following nucleation.
else
CC   -!- FUNCTION: May participate in a complex which severs microtubules in an
CC       ATP-dependent manner. Microtubule severing may promote rapid
CC       reorganization of cellular microtubule arrays.
end case
case <OC:Mammalia>
CC   -!- SUBUNIT: Interacts with KATNA1. This interaction enhances the
CC       microtubule binding and severing activity of KATNA1 and also targets
CC       this activity to the centrosome. This interaction is weakly competed by
CC       KATNBL1 which has a lower affinity for it. Interacts with ASPM; the
CC       katanin complex formation KATNA1:KATNB1 is required for the association
CC       of ASPM. Interacts with dynein, microtubules, NDEL1 and PAFAH1B1.
CC       Interacts with KATNAL1; this interaction is weakly competed by KATNBL1
CC       which has a lower affinity for it. Interacts with CAMSAP2 and CAMSAP3;
CC       leading to regulate the length of CAMSAP-decorated microtubule
CC       stretches.
else case <OC:Metazoa>
CC   -!- SUBUNIT: Interacts with @gn(KATNA1). This interaction enhances the
CC       microtubule binding and severing activity of @gn(KATNA1) and also
CC       targets this activity to the centrosome.
end case
case <OC:Mammalia>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
CC       Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle.
CC       Note=Predominantly cytoplasmic. Localized to the interphase centrosome
CC       and mitotic spindle poles. Localizes within the cytoplasm, partially
CC       overlapping with microtubules, in interphase and to the mitotic spindle
CC       and spindle poles during mitosis.
else case <OC:Metazoa>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
CC       Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle.
CC       Note=Predominantly cytoplasmic. Localized to the interphase centrosome
CC       and mitotic spindle poles.
else
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
end case
CC   -!- SIMILARITY: Belongs to the WD repeat KATNB1 family.
XX
DR   PROSITE; PS00678; WD_REPEATS_1; 3; trigger=no
DR   PROSITE; PS50082; WD_REPEATS_2; 5; trigger=no
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1; trigger=no
DR   Pfam; PF00400; WD40; 6; trigger=no
DR   PRINTS; PR00320; GPROTEINBRPT; 1; trigger=no
DR   REP; Repeat_WD40; WD40; 6; trigger=yes
XX
KW   Cytoplasm
KW   Cytoskeleton
KW   Microtubule
case <OC:Metazoa>
KW   Cell cycle
KW   Cell division
KW   Mitosis
end case
XX
GO   GO:0008017; F:microtubule binding
GO   GO:0051013; P:microtubule severing
GO   GO:0005737; C:cytoplasm
case <OC:Mammalia>
GO   GO:0031117; P:positive regulation of microtubule depolymerization
GO   GO:0007079; P:mitotic chromosome movement towards spindle pole
end case
case <OC:Metazoa>
GO   GO:0005813; C:centrosome
GO   GO:0005819; C:spindle
end case
XX
FT   None
XX
Size: 578-934;
Related: None;
Template: Q9BVA0; Q8BG40; Q4V7Y7; O61585;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.11 2019/11/20
//