AC   MF_03024;
DC   Protein; auto
TR   HAMAP; MF_03024; -; 1; level=0
XX
Names: Katanin_p60_AL1
XX
ID   KATL1
DE   RecName: Full=Katanin p60 ATPase-containing subunit A-like 1;
DE            Short=Katanin p60 subunit A-like 1;
DE            EC=5.6.1.1;
DE   AltName: Full=p60 katanin-like 1;
GN   Name=KATNAL1;
XX
CC   -!- FUNCTION: Regulates microtubule dynamics in Sertoli cells, a process
CC       that is essential for spermiogenesis and male fertility. Severs
CC       microtubules in an ATP-dependent manner, promoting rapid reorganization
CC       of cellular microtubule arrays.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1)
CC         alpha/beta tubulin heterodimers.; EC=5.6.1.1;
case <OC:Mammalia>
CC   -!- SUBUNIT: Interacts with KATNB1 and KATNBL1.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm,
CC       cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle.
CC       Note=Colocalizes with microtubules throughout the basal and adluminal
CC       compartments of Sertoli cells. Localizes within the cytoplasm,
CC       partially overlapping with microtubules, in interphase and to the
CC       mitotic spindle and spindle poles during mitosis.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. Katanin p60 subunit A1
CC       subfamily. A-like 1 sub-subfamily.
XX
DR   PROSITE; PS00674; AAA; 1; trigger=no
DR   Pfam; PF00004; AAA; 1; trigger=no
XX
KW   ATP-binding
KW   Cytoplasm
KW   Cytoskeleton
KW   Isomerase
KW   Microtubule
KW   Nucleotide-binding
XX
GO   GO:0008017; F:microtubule binding
GO   GO:0051013; P:microtubule severing
GO   GO:0005737; C:cytoplasm
GO   GO:0007283; P:spermatogenesis
XX
FT   From: KATL1_HUMAN (Q9BW62)
FT   BINDING         248..255
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G-P-P-G-T-G-K-T
XX
Size: 487-491;
Related: None;
Template: Q9BW62;
Scope:
 Eukaryota; Vertebrata
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.15 2022/11/19
//