AC   MF_03025;
DC   Protein; auto
TR   HAMAP; MF_03025; -; 1; level=0
XX
Names: Katanin_p60_AL2
XX
ID   KATL2
DE   RecName: Full=Katanin p60 ATPase-containing subunit A-like 2;
DE            Short=Katanin p60 subunit A-like 2;
DE            EC=5.6.1.1;
DE   AltName: Full=p60 katanin-like 2;
GN   Name=KATNAL2;
XX
CC   -!- FUNCTION: Severs microtubules in vitro in an ATP-dependent manner. This
CC       activity may promote rapid reorganization of cellular microtubule
CC       arrays.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1)
CC         alpha/beta tubulin heterodimers.; EC=5.6.1.1;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm,
CC       cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole.
CC       Note=Localizes within the cytoplasm, partially overlapping with
CC       microtubules in interphase and to the mitotic spindle and spindle poles
CC       during mitosis.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. Katanin p60 subunit A1
CC       subfamily. A-like 2 sub-subfamily.
XX
DR   PROSITE; PS00674; AAA; 1; trigger=no
DR   PROSITE; PS50896; LISH; 1; trigger=yes
DR   Pfam; PF00004; AAA; 1; trigger=no
DR   Pfam; PF08513; LisH; 1; trigger=no
XX
KW   ATP-binding
KW   Cytoplasm
KW   Cytoskeleton
KW   Isomerase
KW   Microtubule
KW   Nucleotide-binding
XX
GO   GO:0008017; F:microtubule binding
GO   GO:0051013; P:microtubule severing
GO   GO:0005737; C:cytoplasm
XX
FT   From: KATL2_HUMAN (Q8IYT4)
FT   BINDING         294..301
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G-P-P-[GD]-[TLN]-G-K-T
XX
Size: 403-603;
Related: None;
Template: Q8IYT4;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.12 2022/11/19
//