AC   MF_03026;
DC   Protein; auto
TR   HAMAP; MF_03026; -; 1; level=0
XX
Names: LZTS2
XX
ID   LZTS2
case <OC:Mammalia>
DE   RecName: Full=Leucine zipper putative tumor suppressor 2;
DE   AltName: Full=Protein LAPSER1;
else
DE   RecName: Full=Leucine zipper putative tumor suppressor 2 homolog;
DE   AltName: Full=Protein @gn(LAPSER1);
end case
GN   Name=LZTS2; Synonyms=LAPSER1;
XX
case <OC:Mammalia>
CC   -!- FUNCTION: Negative regulator of katanin-mediated microtubule severing
CC       and release from the centrosome. Required for central spindle formation
CC       and the completion of cytokinesis. May negatively regulate axonal
CC       outgrowth by preventing the formation of microtubule bundles that are
CC       necessary for transport within the elongating axon. Negative regulator
CC       of the Wnt signaling pathway. Represses beta-catenin-mediated
CC       transcriptional activation by promoting the nuclear exclusion of beta-
CC       catenin.
else
CC   -!- FUNCTION: Negative regulator of katanin-mediated microtubule severing
CC       and release from the centrosome. Required for central spindle formation
CC       and the completion of cytokinesis. Negative regulator of the Wnt
CC       signaling pathway. Represses beta-catenin-mediated transcriptional
CC       activation by promoting the nuclear exclusion of beta-catenin.
end case
case <OC:Mammalia>
CC   -!- SUBUNIT: Interacts with KATNB1. Also interacts with CTNNB1, gamma-
CC       tubulin and KIF23.
end case
case <OC:Mammalia>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome. Note=Localized to the centrosome
CC       throughout the cell cycle. Localized to the midbody in cells undergoing
CC       cytokinesis.
else
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, centrosome.
end case
CC   -!- SIMILARITY: Belongs to the LZTS2 family.
XX
DR   Pfam; PF06818; Fez1; 1; trigger=no
DR   PROSITE; PS50324; SER_RICH; 0-unlimited; trigger=strict
DR   PROSITE; PS50312; ASP_RICH; 0-unlimited; trigger=strict
DR   PROSITE; PS50313; GLU_RICH; 0-unlimited; trigger=strict
DR   PROSITE; PS50318; LYS_RICH; 0-unlimited; trigger=strict
DR   PROSITE; PS50323; ARG_RICH; 0-unlimited; trigger=strict
DR   General; Coiled_coil; -; 0-unlimited; trigger=strict
XX
KW   Cell cycle
KW   Cell division
KW   Cytoplasm
KW   Cytoskeleton
KW   Microtubule
KW   Mitosis
KW   Wnt signaling pathway
XX
GO   GO:0051013; P:microtubule severing
GO   GO:0000281; P:mitotic cytokinesis
GO   GO:0030178; P:negative regulation of Wnt signaling pathway
GO   GO:0051168; P:nuclear export
GO   GO:0051255; P:spindle midzone assembly
GO   GO:0005737; C:cytoplasm
GO   GO:0005813; C:centrosome
GO   GO:0030496; C:midbody
XX
FT   From: LZTS2_HUMAN (Q9BRK4)
case <OC:Mammalia>
FT   MOTIF           631..640
FT                   /note="Nuclear export signal"
FT   Condition: L-x-x-x-L-x-x-L-x-L
end case
XX
Size: 666-683;
Related: None;
Template: Q9BRK4; Q3LUD4;
Scope:
 Eukaryota; Vertebrata
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.12 2019/11/20
//