AC   MF_03029;
DC   Protein; auto
TR   HAMAP; MF_03029; -; 1; level=0
XX
Names: WDR12
XX
case <OC:Fungi>
ID   YTM1
else
ID   WDR12
end case
case <OC:Vertebrata>
DE   RecName: Full=Ribosome biogenesis protein @gn(WDR12);
DE   AltName: Full=WD repeat-containing protein 12;
else case <OC:Fungi>
DE   RecName: Full=Ribosome biogenesis protein @gn(YTM1);
else
DE   RecName: Full=Ribosome biogenesis protein WDR12 homolog;
end case
case <OC:Vertebrata>
GN   Name=WDR12;
else case <OC:Caenorhabditis>
GN   Name=wdr-12;
else case <OC:Fungi>
GN   Name=YTM1;
end case
XX
case <OC:Vertebrata>
CC   -!- FUNCTION: Component of the PeBoW complex, which is required for
CC       maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome.
else case <OC:Fungi>
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome.
else
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit.
end case
case <OC:Vertebrata>
CC   -!- SUBUNIT: Component of the PeBoW complex, composed of @gn(BOP1),
CC       @gn(PES1) and @gn(WDR12). Within the PeBoW complex @gn(BOP1) interacts
CC       directly with @gn(PES1) and @gn(WDR12). The PeBoW complex also
CC       associates with the 66S pre-ribosome.
else case <OC:Fungi>
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of @gn(ERB1),
CC       @gn(NOP7) and @gn(YTM1). Within the NOP7 complex @gn(ERB1) appears to
CC       interact directly with @gn(NOP7) and @gn(YTM1). The NOP7 complex also
CC       associates with the 66S pre-ribosome.
end case
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus, nucleoplasm.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
XX
DR   PROSITE; PS00678; WD_REPEATS_1; 2; trigger=no
DR   PROSITE; PS50082; WD_REPEATS_2; 5; trigger=no
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1; trigger=no
DR   Pfam; PF08154; NLE; 1; trigger=no
DR   Pfam; PF00400; WD40; 7; trigger=no
DR   REP; Repeat_WD40; WD40; 6-7; trigger=yes
XX
KW   Nucleus
KW   Ribosome biogenesis
KW   rRNA processing
XX
GO   GO:0043021; F:ribonucleoprotein complex binding
GO   GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO   GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO   GO:0042273; P:ribosomal large subunit biogenesis
GO   GO:0005634; C:nucleus
GO   GO:0005730; C:nucleolus
GO   GO:0030687; C:preribosome, large subunit precursor
XX
FT   None
XX
Size: 416-528;
Related: None;
Template: Q9GZL7; Q12024;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.9 2019/11/20
//