AC   MF_03030;
DC   Protein; auto
TR   HAMAP; MF_03030; -; 1; level=0
XX
Names: MGME1
XX
ID   MGME1
DE   RecName: Full=Mitochondrial genome maintenance exonuclease 1;
DE            EC=3.1.-.-;
case <OC:Vertebrata>
GN   Name=MGME1;
end case
XX
case <OC:Mammalia>
CC   -!- FUNCTION: Metal-dependent single-stranded DNA (ssDNA) exonuclease
CC       involved in mitochondrial genome maintenance. Has preference for 5'-3'
CC       exonuclease activity but is also capable of endoduclease activity on
CC       linear substrates. Necessary for maintenance of proper 7S DNA levels.
CC       Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the
CC       processing of displaced DNA containing Okazaki fragments during RNA-
CC       primed DNA synthesis on the lagging strand or via processing of DNA
CC       flaps during long-patch base excision repair.
else case <OC:Vertebrata>
CC   -!- FUNCTION: Metal-dependent single-stranded DNA (ssDNA) exonuclease
CC       involved in mitochondrial genome maintenance. Has preference for 5'-3'
CC       exonuclease activity. Necessary for maintenance of proper 7S DNA
CC       levels. Probably involved in mitochondrial DNA (mtDNA) repair.
else
CC   -!- FUNCTION: Metal-dependent single-stranded DNA (ssDNA) exonuclease
CC       involved in mitochondrial genome maintenance.
end case
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
case not <AnyFeature:TransitM>
CC   -!- MISCELLANEOUS: This protein may be expected to contain an N-terminal
CC       transit peptide but none has been predicted.
end case
CC   -!- SIMILARITY: Belongs to the MGME1 family.
XX
DR   General; TransitM; -; 0-1; trigger=yes
XX
KW   Exonuclease
KW   Hydrolase
KW   Mitochondrion
KW   Nuclease
XX
GO   GO:0005739; C:mitochondrion
GO   GO:0000002; P:mitochondrial genome maintenance
GO   GO:0043504; P:mitochondrial DNA repair
GO   GO:0008297; F:single-stranded DNA exodeoxyribonuclease activity
XX
FT   From: MGME1_HUMAN (Q9BQP7)
FT   ACT_SITE        238
FT   Condition: D
FT   ACT_SITE        251
FT   Condition: [DE]
FT   ACT_SITE        253
FT   Condition: K
XX
Size: 182-455;
Related: None;
Template: Q9BQP7;
Scope:
 Eukaryota; Metazoa
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.9 2019/11/20
//