AC   MF_03033;
DC   Protein; auto
TR   HAMAP; MF_03033; -; 1; level=0
XX
Names: AGO4
XX
ID   AGO4
DE   RecName: Full=Protein argonaute-4;
DE            Short=Argonaute4;
DE   AltName: Full=Eukaryotic translation initiation factor 2C 4;
DE            Short=eIF-2C 4;
DE            Short=eIF2C 4;
GN   Name=EIF2C4; Synonyms=AGO4;
XX
CC   -!- FUNCTION: Required for RNA-mediated gene silencing (RNAi). Binds to
CC       short RNAs such as microRNAs (miRNAs) and represses the translation of
CC       mRNAs which are complementary to them. Lacks endonuclease activity and
CC       does not appear to cleave target mRNAs.
case <OC:Mammalia>
CC   -!- SUBUNIT: Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B.
CC       Interacts with ZFP36.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, P-body.
CC   -!- SIMILARITY: Belongs to the argonaute family. Ago subfamily.
XX
DR   PROSITE; PS50821; PAZ; 1; trigger=yes
DR   PROSITE; PS50822; PIWI; 1; trigger=yes
DR   Pfam; PF08699; DUF1785; 1; trigger=no
DR   Pfam; PF02170; PAZ; 1; trigger=no
DR   Pfam; PF02171; Piwi; 1; trigger=no
XX
KW   Cytoplasm
KW   Ribonucleoprotein
KW   RNA-binding
KW   RNA-mediated gene silencing
KW   Translation regulation
XX
GO   GO:0035198; F:miRNA binding
GO   GO:0035278; P:miRNA-mediated gene silencing by inhibition of translation
GO   GO:0016442; C:RISC complex
XX
FT   None
XX
Size: 794-884;
Related: None;
Template: Q9HCK5; Q8CJF8;
Scope:
 Eukaryota; Vertebrata
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.11 2022/02/15
//