AC MF_03034; DC Protein; auto TR HAMAP; MF_03034; -; 1; level=0 XX Names: TRBP2 XX ID TRBP2 DE RecName: Full=RISC-loading complex subunit @gn(TARBP2); GN Name=TARBP2; XX CC -!- FUNCTION: Required for formation of the RNA induced silencing complex CC (RISC). Component of the RISC loading complex (RLC), also known as the CC micro-RNA (miRNA) loading complex (miRLC), which is composed of CC @gn(DICER1), @gn(AGO2) and @gn(TARBP2). Within the RLC/miRLC, CC @gn(DICER1) and @gn(TARBP2) are required to process precursor miRNAs CC (pre-miRNAs) to mature miRNAs and then load them onto @gn(AGO2). CC @gn(AGO2) bound to the mature miRNA constitutes the minimal RISC and CC may subsequently dissociate from @gn(DICER1) and @gn(TARBP2). May also CC play a role in the production of short interfering RNAs (siRNAs) from CC double-stranded RNA (dsRNA) by @gn(DICER1). case CC -!- SUBUNIT: Self-associates. Component of the RISC loading complex (RLC), CC or micro-RNA (miRNA) loading complex (miRLC), which is composed of CC DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also CC referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its CC protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with CC DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a CC large RNA-induced silencing complex (RISC). else CC -!- SUBUNIT: Self-associates. Component of the RISC loading complex (RLC), CC or micro-RNA (miRNA) loading complex (miRLC), which is composed of CC @gn(DICER1), @gn(AGO2) and @gn(TARBP2). Note that the trimeric CC RLC/miRLC is also referred to as RISC. end case case CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. CC Nucleus. else CC -!- SUBCELLULAR LOCATION: Cytoplasm. end case CC -!- SIMILARITY: Belongs to the TARBP2 family. XX DR PROSITE; PS50137; DS_RBD; 3; trigger=yes DR Pfam; PF00035; dsrm; 2; trigger=no XX KW Cytoplasm KW RNA-binding KW RNA-mediated gene silencing KW Translation regulation case KW Nucleus end case XX GO GO:0035197; F:siRNA binding GO GO:0035198; F:miRNA binding GO GO:0042803; F:protein homodimerization activity GO GO:0030422; P:siRNA processing GO GO:0098795; P:global gene silencing by mRNA cleavage GO GO:0031054; P:pre-miRNA processing GO GO:0070922; P:RISC complex assembly GO GO:0016442; C:RISC complex XX FT From: TRBP2_HUMAN (Q15633) case FT REGION 22..105 FT /note="Sufficient for interaction with PRKRA" FT REGION 152..234 FT /note="Sufficient for interaction with PRKRA" FT REGION 228..366 FT /note="Sufficient for interaction with DICER1" FT REGION 287..366 FT /note="Sufficient for interaction with PRKRA" end case XX Size: 319-366; Related: None; Template: Q15633; P97473; Scope: Eukaryota; Vertebrata Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.9 2022/05/03 //