AC   MF_03036;
DC   Protein; auto
TR   HAMAP; MF_03036; -; 1; level=0
XX
Names: Nuc_phosphate_hydrolase
XX
ID   DNPH1
case <OC:Mammalia>
DE   RecName: Full=2'-deoxynucleoside 5'-phosphate N-hydrolase 1;
DE            EC=3.2.2.-;
DE   AltName: Full=c-Myc-responsive protein @gn(RCL);
else case <OC:Vertebrata>
DE   RecName: Full=2'-deoxynucleoside 5'-phosphate N-hydrolase 1;
DE            EC=3.2.2.-;
else
DE   RecName: Full=Putative 2'-deoxynucleoside 5'-phosphate N-hydrolase 1;
DE            EC=3.2.2.-;
end case
case <OC:Mammalia>
GN   Name=DNPH1; Synonyms=RCL;
else case <OC:Vertebrata>
GN   Name=DNPH1;
end case
XX
case <OC:Vertebrata>
CC   -!- FUNCTION: Catalyzes the cleavage of the N-glycosidic bond of
CC       deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate
CC       and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates
CC       containing purine bases are preferred to those containing pyrimidine
CC       bases.
else
CC   -!- FUNCTION: Catalyzes the cleavage of the N-glycosidic bond of
CC       deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate
CC       and a purine or pyrimidine base.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-
CC         deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase;
CC         Xref=Rhea:RHEA:57852, ChEBI:CHEBI:15377, ChEBI:CHEBI:26432,
CC         ChEBI:CHEBI:62877, ChEBI:CHEBI:142209;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a purine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-
CC         D-ribose 5-phosphate + a purine nucleobase; Xref=Rhea:RHEA:51132,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:26386, ChEBI:CHEBI:62877,
CC         ChEBI:CHEBI:142198;
CC   -!- SUBUNIT: Monomer and homodimer.
case <OC:Eukaryota>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
end case
CC   -!- SIMILARITY: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase
CC       1 family.
XX
DR   Pfam; PF05014; Nuc_deoxyrib_tr; 1; trigger=no
XX
case <OC:Eukaryota>
KW   Cytoplasm
KW   Nucleus
end case
KW   Glycosidase
KW   Hydrolase
KW   Nucleotide metabolism
XX
GO   GO:0016799; F:hydrolase activity, hydrolyzing N-glycosyl compounds
GO   GO:0009116; P:nucleoside metabolic process
case <OC:Mammalia>
GO   GO:0042803; F:protein homodimerization activity
end case
case <OC:Eukaryota>
GO   GO:0005634; C:nucleus
GO   GO:0005737; C:cytoplasm
end case
XX
FT   From: DNPH1_RAT (O35820)
case <OC:Mammalia>
FT   INIT_MET        1
FT                   /note="Removed"
FT   Condition: M
end case
FT   BINDING         13..19
FT                   /ligand="substrate"
FT                   /ligand_note="ligand shared between homodimeric
FT                   partners"
FT                   /note="in other chain"
FT   Condition: [YF]-x-[CS]-G-S-[IM]-R
FT   BINDING         117..119
FT                   /ligand="substrate"
FT                   /ligand_note="ligand shared between homodimeric
FT                   partners"
FT   Condition: S-[ASG]-[ML]
FT   BINDING         28
FT                   /ligand="substrate"
FT                   /ligand_note="ligand shared between homodimeric
FT                   partners"
FT                   /note="in other chain"
FT   Condition: Y
FT   BINDING         93
FT                   /ligand="substrate"
FT                   /ligand_note="ligand shared between homodimeric
FT                   partners"
FT                   /note="in other chain"
FT   Condition: E
XX
Size: 105-174;
Related: None;
Template: O35820; O43598;
Scope:
 Bacteria
 Eukaryota
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.14 2022/05/14
//