AC   MF_03037;
DC   Protein; auto
TR   HAMAP; MF_03037; -; 1; level=0
XX
Names: ciao1
XX
ID   CIAO1
case <OC:Mammalia>
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein CIAO1;
DE   AltName: Full=WD repeat-containing protein 39;
else case <OC:Vertebrata>
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein @gn(CIAO1);
DE   AltName: Full=WD repeat-containing protein 39;
else case <OC:Arthropoda>
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein Ciao1;
else case <OC:Fungi>
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1;
else
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog;
end case
case <OC:Vertebrata>
GN   Name=CIAO1;
else case <OC:Arthropoda>
GN   Name=Ciao1;
else case <OC:Fungi>
GN   Name=CIA1;
end case
XX
case <OC:Mammalia>
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to
CC       specifically modulate the transactivation activity of WT1. As part of
CC       the mitotic spindle-associated MMXD complex it may play a role in
CC       chromosome segregation.
else case <OC:Vertebrata>
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into extramitochondrial Fe/S proteins.
else
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins.
end case
case <OC:Mammalia>
CC   -!- SUBUNIT: Component of the CIA complex. Component of the MMXD complex,
CC       which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with
CC       WT1. Interacts with FAM96A.
else case <OC:Vertebrata>
CC   -!- SUBUNIT: Component of the CIA complex.
else case <OC:Saccharomycetes>
CC   -!- SUBUNIT: Interacts with @gn(NAR1).
end case
case <OC:Saccharomycetes>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Preferentially localized
CC       to the nucleus.
end case
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family.
XX
DR   REP; Repeat_WD40; WD40; 7; trigger=yes
DR   PROSITE; PS00678; WD_REPEATS_1; 1; trigger=no
DR   PROSITE; PS50082; WD_REPEATS_2; 7; trigger=no
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1; trigger=no
DR   Pfam; PF00400; WD40; 7; trigger=no
XX
case <OC:Mammalia>
KW   Chromosome partition
end case
case <OC:Saccharomycetes>
KW   Cytoplasm
KW   Nucleus
end case
XX
case <OC:Mammalia>
GO   GO:0097361; C:CIA complex
GO   GO:0071817; C:MMXD complex
end case
GO   GO:0016226; P:iron-sulfur cluster assembly
XX
FT   None
XX
Size: 313-506;
Related: None;
Template: O76071; Q05583;
Scope:
 Eukaryota
Fusion:
 Nter: MF_03039
 Cter: None
Duplicate: in SALSA
Plasmid: None
Comments: None
XX
# Revision 1.6 2019/11/20
//