AC   MF_03040;
DC   Protein; auto
TR   HAMAP; MF_03040; -; 1; level=0
XX
Names: USB1
XX
ID   USB1
DE   RecName: Full=U6 snRNA phosphodiesterase;
DE            EC=3.1.4.-;
case <OC:Vertebrata> or <OC:Fungi>
GN   Name=USB1;
end case
XX
case <OC:Mammalia>
CC   -!- FUNCTION: Phosphodiesterase responsible for the U6 snRNA 3' end
CC       processing. Acts as an exoribonuclease (RNase) responsible for trimming
CC       the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule,
CC       leading to the formation of mature U6 snRNA 3' end-terminated with a
CC       2',3'-cyclic phosphate.
else
CC   -!- FUNCTION: Phosphodiesterase responsible for the U6 snRNA 3' end
CC       processing. Acts as an exoribonuclease (RNase) responsible for trimming
CC       the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule,
CC       leading to the formation of mature U6 snRNA.
end case
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the 2H phosphoesterase superfamily. USB1 family.
XX
DR   Pfam; PF09749; HVSL; 1; trigger=no
XX
KW   Hydrolase
KW   Nuclease
KW   Nucleus
XX
GO   GO:0005634; C:nucleus
GO   GO:0000175; F:3'-5'-RNA exonuclease activity
GO   GO:1990838; F:poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends
GO   GO:0034477; P:U6 snRNA 3'-end processing
XX
FT   From: USB1_YEAST (Q12208)
FT   ACT_SITE        133
FT                   /note="Proton donor/acceptor"
FT   Condition: H
FT   ACT_SITE        231
FT                   /note="Proton donor/acceptor"
FT   Condition: H
XX
Size: 227-372;
Related: None;
Template: Q12208; Q9BQ65;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.8 2023/02/07
//