AC   MF_03041;
DC   Protein; auto
TR   HAMAP; MF_03041; -; 1; level=0
XX
Names: SPDLY
XX
ID   SPDLY
DE   RecName: Full=Protein Spindly;
DE   AltName: Full=Coiled-coil domain-containing protein 99;
DE   AltName: Full=Spindle apparatus coiled-coil domain-containing protein 1;
GN   Name=SPDL1; Synonyms=CCDC99;
XX
case <OC:Mammalia>
CC   -!- FUNCTION: Required for the localization of dynein and dynactin to the
CC       mitotic kintochore. Dynein is believed to control the initial lateral
CC       interaction between the kinetochore and spindle microtubules and to
CC       facilitate the subsequent formation of end-on kinetochore-microtubule
CC       attachments mediated by the NDC80 complex. Also required for correct
CC       spindle orientation. Does not appear to be required for the removal of
CC       spindle assembly checkpoint (SAC) proteins from the kinetochore upon
CC       bipolar spindle attachment.
else
CC   -!- FUNCTION: Required for the localization of dynein and dynactin to the
CC       mitotic kintochore. Dynein is believed to control the initial lateral
CC       interaction between the kinetochore and spindle microtubules and to
CC       facilitate the subsequent formation of end-on kinetochore-microtubule
CC       attachments mediated by the NDC80 complex.
end case
case <OC:Mammalia>
CC   -!- SUBUNIT: Interacts with KNTC1 and ZW10. These interactions appear weak
CC       and may be transient or indirect.
end case
case <OC:Mammalia>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome. Chromosome, centromere, kinetochore. Nucleus.
CC       Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the nucleus in
CC       interphase and to the kinetochore in early prometaphase. Relocalizes to
CC       the mitotic spindle pole before metaphase and is subsequently lost from
CC       the spindle poles after chromosome congression is completed. Removal of
CC       this protein from the kinetochore requires the dynein/dynactin complex.
else
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore.
end case
CC   -!- SIMILARITY: Belongs to the Spindly family.
XX
DR   General; Coiled_coil; -; 1-unlimited; trigger=yes
XX
KW   Centromere
KW   Cell cycle
KW   Cell division
KW   Chromosome
KW   Kinetochore
KW   Mitosis
case <OC:Mammalia>
KW   Cytoplasm
KW   Cytoskeleton
KW   Nucleus
end case
XX
GO   GO:0043515; F:kinetochore binding
GO   GO:0034501; P:protein localization to kinetochore
GO   GO:0000940; C:outer kinetochore
XX
FT   None
XX
Size: 590-611;
Related: None;
Template: Q96EA4;
Scope:
 Eukaryota; Vertebrata
Fusion:
 Nter: None
 Cter: None
Duplicate: in XENLA
Plasmid: None
Comments: None
XX
# Revision 1.10 2021/06/04
//