AC   MF_03043;
DC   Protein; auto
TR   HAMAP; MF_03043; -; 1; level=0
XX
Names: QTRT2
XX
ID   QTRT2
DE   RecName: Full=Queuine tRNA-ribosyltransferase accessory subunit 2;
DE   AltName: Full=Queuine tRNA-ribosyltransferase domain-containing protein 1;
case <OC:Vertebrata>
GN   Name=QTRT2;
else case <OC:Caenorhabditis>
GN   Name=tgt-2;
end case
XX
CC   -!- FUNCTION: Non-catalytic subunit of the queuine tRNA-ribosyltransferase
CC       (TGT) that catalyzes the base-exchange of a guanine (G) residue with
CC       queuine (Q) at position 34 (anticodon wobble position) in tRNAs with
CC       GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the
CC       hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-
CC       cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
end case
case <OC:Vertebrata>
CC   -!- SUBUNIT: Heterodimer of a catalytic subunit @gn(QTRT1) and an accessory
CC       subunit @gn(QTRT2).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion outer membrane;
CC       Peripheral membrane protein; Cytoplasmic side. Note=May associate with
CC       the mitochondrion outer membrane.
else
CC   -!- SUBUNIT: Heterodimer of a catalytic subunit and an accessory subunit.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
end case
CC   -!- SIMILARITY: Belongs to the queuine tRNA-ribosyltransferase family.
CC       QTRT2 subfamily.
XX
DR   Pfam; PF01702; TGT; 1; trigger=no
DR   NCBIfam; TIGR00449; tgt_general; 1; trigger=no
XX
KW   Cytoplasm
case <OC:Vertebrata>
KW   Mitochondrion
KW   Mitochondrion outer membrane
KW   Membrane
end case
KW   tRNA processing
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
GO   GO:0005737; C:cytoplasm
case <OC:Vertebrata>
GO   GO:0005741; C:mitochondrial outer membrane
end case
GO   GO:0008479; F:tRNA-guanosine(34) queuine transglycosylase activity
GO   GO:0101030; P:tRNA-guanine transglycosylation
XX
FT   From: QTRT2_MOUSE (B8ZXI1)
FT   BINDING         351
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         353
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         356
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         382
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: H
XX
Size: 369-432;
Related: None;
Template: B8ZXI1;
Scope:
 Eukaryota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.14 2023/07/27
//